Interaction of High- and Low-Risk Human Papillomavirus Genotypes is Associated with a Reduced Risk of Developing Cervical Cancer.

Infectious disorders drug targets Pub Date : 2024-09-20 DOI:10.2174/0118715265307980240826060516

Malihe Hasanzadeh, Marzieh Rejali, Ghazaleh Khalili-Tanha, Mehraneh Mehramiz, Negar Yavari, Elham Nazari, Parnian Malakuti, Faezeh Maleki, Ghazale Ghorbannezhad, Mahdi Rafiei, Anahita Mirani, Negar Gholampoor-Shamkani, Hoda Saber, Leila Mousavi Seresht, Zohreh Emamdadi-Aliabad, Zahra Mahdian, Mahdieh Akbari, Gordon A Ferns, Ala-Eddin Al Moustafa, Amir Avan

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Abstract

Introduction: Cervical cancer is among the most common types of cancer in women and is associated with human papillomavirus (HPV) infection. The association between cervical cancer and high-risk HPV infection has been well documented. However, the effect of simultaneous infection with high- and low-risk HPV or low-risk HPV alone on the risk of developing cervical malignancy remains unanswered in guidelines.

Method: We investigated the association of high and low-risk HPVs (HR or LR) genotypes with cervical carcinoma risk and pathological and cytological information in cases recruited from a population-based cohort study of 790 patients. Correlation matrix and t-test were used for analysis.

Results: The percentage of HR+LR and HR-HPV16/18 were 9.30% and 11.20% in class II, 7.15% and 7.10% in class IV, and 7.15% and 5.80% in As-CUS smears. Interestingly, concurrent infection with HR-HPV and LR-HPV types led to a significant reduction in the risk of developing malignancy compared to the high-risk group (OR=0.3 (0.098-0.925), pvalue=0.04). The percentage of individuals with cervical malignancy was 10.2% and 28.2% within the co-infected and the HR-HPV participants.

Conclusion: Our findings suggest that simultaneous infection with high- and low-risk HPV may reduce the risk of cervical malignancy.

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高危和低危人乳头瘤病毒基因型的相互作用与宫颈癌发病风险降低有关。

导言：宫颈癌是女性最常见的癌症之一，与人类乳头瘤病毒（HPV）感染有关。宫颈癌与高危型人乳头瘤病毒感染之间的关系已得到充分证实。然而，同时感染高危和低危型 HPV 或仅感染低危型 HPV 对宫颈恶性肿瘤发病风险的影响仍未在指南中找到答案：我们调查了高危和低危HPV（HR或LR）基因型与宫颈癌风险、病理学和细胞学信息的关系，这些病例来自一项基于人群的队列研究，共有790名患者。分析采用了相关矩阵和 t 检验：结果：HR+LR和HR-HPV16/18在II级涂片中的比例分别为9.30%和11.20%，在IV级涂片中的比例分别为7.15%和7.10%，在As-CUS涂片中的比例分别为7.15%和5.80%。有趣的是，与高危组相比，同时感染 HR-HPV 和 LR-HPV 类型可显著降低罹患恶性肿瘤的风险（OR=0.3 (0.098-0.925)，pvalue=0.04）。合并感染者和HR-HPV感染者中患宫颈恶性肿瘤的比例分别为10.2%和28.2%：我们的研究结果表明，同时感染高危和低危 HPV 可降低宫颈恶性肿瘤的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Infectious disorders drug targets

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