Valosin-containing protein: A potential therapeutic target for cardiovascular diseases

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-09-21 DOI:10.1016/j.arr.2024.102511

Nameerah Rakhe, Lokesh Kumar Bhatt

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引用次数: 0

Abstract

Valosin-containing protein (VCP), also known as p97, plays a crucial role in various cellular processes, including protein degradation, endoplasmic reticulum-associated degradation, and cell cycle regulation. While extensive research has been focused on VCP's involvement in protein homeostasis and its implications in neurodegenerative diseases, emerging evidence suggests a potential link between VCP and cardiovascular health. VCP is a key regulator of mitochondrial function, and its overexpression or mutations lead to pathogenic diseases and cellular stress responses. The present review explores VCP's roles in numerous cardiovascular disorders including myocardial ischemia/reperfusion injury, cardiac hypertrophy, and heart failure. The review dwells on the roles of VCP in modifying mitochondrial activity, promoting S-nitrosylation, regulating mTOR signalling and demonstrating cardioprotective effects. Further research into VCP might lead to novel interventions for cardiovascular disease, particularly those involving ischemia/reperfusion injury and hypertrophy.

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含缬氨酸蛋白：心血管疾病的潜在治疗靶点

含缬氨酸蛋白（VCP），又称 p97，在蛋白质降解、内质网相关降解和细胞周期调控等多种细胞过程中发挥着至关重要的作用。虽然大量研究都集中在 VCP 参与蛋白质平衡及其对神经退行性疾病的影响上，但新出现的证据表明 VCP 与心血管健康之间存在潜在联系。VCP 是线粒体功能的关键调节因子，其过度表达或突变会导致致病性疾病和细胞应激反应。本综述探讨了 VCP 在心肌缺血/再灌注损伤、心肌肥厚和心力衰竭等多种心血管疾病中的作用。综述详述了 VCP 在改变线粒体活性、促进 S-亚硝基化、调节 mTOR 信号传导和显示心脏保护作用方面的作用。对 VCP 的进一步研究可能会为心血管疾病，尤其是涉及缺血/再灌注损伤和肥大的疾病带来新的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.