Plasma estrogen levels and aneurysmal subarachnoid hemorrhage in women.

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

World neurosurgery Pub Date : 2024-09-21 DOI:10.1016/j.wneu.2024.09.083

Pui Man Rosalind Lai, Monik Jimenez, Kathryn Rexrode, Rose Du

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Abstract

Objectives: Aneurysmal subarachnoid hemorrhage is more prevalent in post-menopausal women and it has been postulated that this relationship is hormonally driven by lower circulating levels of estrogens. We examined the association between circulating plasma estrogen levels and subsequent development of aneurysmal subarachnoid hemorrhage in women.

Methods: Women from the Nurses' Health Study with confirmed aneurysmal subarachnoid hemorrhage (n=38) were matched with controls (n=38) on age, smoking, menopausal status, and other reproductive factors. Plasma estriol, estradiol and sex hormone-binding globulin (SHBG) were measured at baseline, prior to the development of aSAH. Conditional logistic regressions were performed to assess the association between hormone levels and incident aSAH.

Results: Plasma estradiol, estriol, and SHBG were not associated with the subsequent development of aneurysmal subarachnoid hemorrhage. Women with a history of current or former smoking were associated with lower levels of circulating estriol (β = -0.35±0.12, p=0.004), and estradiol (β = -0.63±0.16, p=0.0002) levels.

Conclusions: In this study, we did not find an association between estrogen levels and incidence of aneurysmal subarachnoid hemorrhage in women.

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女性血浆雌激素水平与动脉瘤性蛛网膜下腔出血。

目的：动脉瘤性蛛网膜下腔出血在绝经后女性中发病率更高，有人推测这种关系是由循环中较低水平的雌激素驱动的。我们研究了女性循环血浆雌激素水平与随后发生动脉瘤性蛛网膜下腔出血之间的关系：方法：将确诊动脉瘤性蛛网膜下腔出血的护士健康研究（Nurses' Health Study）妇女（38 人）与对照组（38 人）在年龄、吸烟、绝经状态和其他生殖因素方面进行配对。在发生蛛网膜下腔出血之前，对血浆雌三醇、雌二醇和性激素结合球蛋白（SHBG）进行基线测量。结果显示：血浆雌二醇、雌三醇、雌二醇和性激素结合球蛋白（SHBG）的水平均高于雌激素水平：结果：血浆雌二醇、雌三醇和SHBG与随后发生的动脉瘤性蛛网膜下腔出血无关。有吸烟史或曾经吸烟的女性，其循环雌三醇（β = -0.35±0.12，p=0.004）和雌二醇（β = -0.63±0.16，p=0.0002）水平较低：在这项研究中，我们没有发现雌激素水平与女性动脉瘤性蛛网膜下腔出血的发病率之间存在关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World neurosurgery CLINICAL NEUROLOGY-SURGERY

CiteScore

3.90

自引率

15.00%

发文量

1765

审稿时长

47 days

期刊介绍： World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The journal''s mission is to: -To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care. -To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide. -To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients. Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS