Rates of Visual Field Progression Before and After the Onset of Atrial Fibrillation.

IF 2 4区 医学 Q2 OPHTHALMOLOGY
Journal of Glaucoma Pub Date : 2024-12-01 Epub Date: 2024-09-25 DOI:10.1097/IJG.0000000000002500
Takashi Nishida, Sasan Moghimi, Wang Jin, Linda M Zangwill, Robert N Weinreb
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引用次数: 0

Abstract

Prcis: This case-control study investigated the effect of atrial fibrillation (AF) on the progression of glaucoma. The presence of AF and related microvascular damage was associated with a slightly faster visual field loss in glaucoma patients.

Purpose: To investigate the effect of atrial fibrillation (AF) on glaucoma progression.

Methods: In this longitudinal case-control study, a total of 144 eyes from 105 patients with primary open angle glaucoma were included. Forty-eight eyes of case developed AF during the follow-up followed for 15.6 years. Ninety-six eyes of control that did not have AF at baseline or during follow-up matched for age, baseline glaucoma severity, and follow-up period were followed for an average of 14.7 years. Mixed-effects linear models were used to calculate the difference in the VF MD slopes before and after the AF. CHADS 2 and CHA 2 DS 2 -VASc scores were used to evaluate the risk of thrombosis event, and related microvascular damage was assessed based on these scores.

Results: The rate of VF MD change was -0.20 (-0.42 to 0.02) dB/y before AF and -0.28 (-0.47 to -0.09) dB/y after AF for the patients with AF, and -0.21 (-0.25 to -0.17) dB/y for the control. In the multivariable models, the VF slope difference before and after the onset of AF [-0.10 (-0.14 to -0.05) dB/y, P <0.001], higher CHADS 2 score [-0.07 (-0.13 to 0.00) dB/y per 1 unit, P =0.040], and higher CHA 2 DS 2 -VASc score [-0.05 (-0.10 to 0.00) dB/y per 1 unit, P =0.039] were associated with faster VF MD loss.

Conclusions: The presence of atrial fibrillation and related microvascular damage might accelerate visual field loss. This underscores the need for a comprehensive medical history and management of cardiovascular risk factors to mitigate increased VF loss in glaucoma.

心房颤动发生前后的视野恶化率
摘要这项病例对照研究调查了心房颤动(AF)对青光眼进展的影响。目的:研究心房颤动(AF)对青光眼进展的影响:在这项纵向病例对照研究中,共纳入了 105 名原发性开角型青光眼患者的 144 只眼睛。48例患者在15.6年的随访期间出现房颤。对照组中有 96 只眼睛在基线和随访期间均未出现房颤,他们的年龄、基线青光眼严重程度和随访时间相匹配,随访时间平均为 14.7 年。采用混合效应线性模型计算房颤前后 VF MD 斜率的差异。采用CHADS2和CHA2DS2-VASc评分来评估血栓事件的风险,并根据这些评分评估相关的微血管损伤:房颤患者房颤前的VF MD变化率为-0.20(-0.42至0.02)dB/y,房颤后为-0.28(-0.47至-0.09)dB/y,对照组为-0.21(-0.25至-0.17)dB/y。在多变量模型中,房颤发生前后的 VF 斜率差(-0.10(-0.14 至-0.05)dB/y,PConclusions:心房颤动和相关的微血管损伤可能会加速视野缺损。这突出表明,需要全面了解病史并控制心血管风险因素,以减轻青光眼患者视野缺损的增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Glaucoma
Journal of Glaucoma 医学-眼科学
CiteScore
4.20
自引率
10.00%
发文量
330
审稿时长
4-8 weeks
期刊介绍: The Journal of Glaucoma is a peer reviewed journal addressing the spectrum of issues affecting definition, diagnosis, and management of glaucoma and providing a forum for lively and stimulating discussion of clinical, scientific, and socioeconomic factors affecting care of glaucoma patients.
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