Congential nasolacrimal duct obstruction: investigating the role of systemic inflammation through novel biomakers.

IF 1.4 4区医学 Q3 OPHTHALMOLOGY

International Ophthalmology Pub Date : 2024-09-24 DOI:10.1007/s10792-024-03314-3

Emine Savran Elibol, Nejla Tükenmez Dikmen

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引用次数: 0

Abstract

Objective: Congenital nasolacrimal duct obstruction (CNLDO) is a common lacrimal system anomaly in newborns and infants. We aimed to evaluate the role of inflammation in the pathogenesis of persistent CNLDO and its potential use in diagnosis and follow up, focusing on novel inflammatory biomarkers: Systemic Immune-Inflammation Index (SII), Neutrophil-to-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR), Red cell distribution width (RDW), and Mean platelet volume (MPV).

Methods: A retrospective case-control study involving 76 CNLDO patients and 47 age-matched healthy controls was conducted. Complete blood count parameters were analyzed to calculate SII, NLR, PLR, RDW, and MPV. Receiver Operating Characteristic (ROC) analysis determined the diagnostic efficacy of these markers.

Results: SII, RDW, and neutrophil count were significantly elevated in the CNLDO group (p < 0.05). An elevated SII (cutoff > 200.9) demonstrated a sensitivity of 63.2% and a specificity of 63.8%. ROC analysis (AUC = 61.7%, p = 0.029) indicated that SII is a more significant marker for diagnosing CNLDO compared to NLR and PLR.

Conclusion: Elevated SII, indicative of systemic inflammation may serve as a significant biomarker in the diagnosis of CNLDO that does not resolve spontaneously and requires probing. SII > 200.9 acts as a threshold that aids in the diagnosis of persistent CNLDO. Being a valuable biomarker, SII can be used in monitoring patients with CNLDO and in identifying those who will require advanced treatment like probing. Prospective studies are essential to validate these findings.

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先天性鼻泪管阻塞：通过新型生物制剂研究全身炎症的作用。

目的：先天性鼻泪管阻塞（CNLDO）是新生儿和婴儿常见的泪道系统异常。我们旨在评估炎症在持续性 CNLDO 发病机制中的作用及其在诊断和随访中的潜在用途，重点关注新型炎症生物标志物：全身免疫炎症指数（SII）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、红细胞分布宽度（RDW）和平均血小板体积（MPV）：一项回顾性病例对照研究涉及 76 名 CNLDO 患者和 47 名年龄匹配的健康对照者。分析全血细胞计数参数以计算 SII、NLR、PLR、RDW 和 MPV。接收者操作特征（ROC）分析确定了这些指标的诊断效果：结果：SII、RDW 和中性粒细胞计数在 CNLDO 组明显升高（p 200.9），灵敏度为 63.2%，特异度为 63.8%。ROC 分析（AUC = 61.7%，P = 0.029）表明，与 NLR 和 PLR 相比，SII 是诊断 CNLDO 的更重要标志物：结论：表明全身炎症的 SII 升高可作为诊断 CNLDO 的重要生物标志物，因为 CNLDO 无法自行缓解，需要进行探查。SII > 200.9 是一个阈值，有助于诊断持续性 CNLDO。作为一种有价值的生物标志物，SII 可用于监测 CNLDO 患者，并确定哪些患者需要进行探查等高级治疗。前瞻性研究对于验证这些发现至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

451

期刊介绍： International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.