{"title":"Myopathy in Statin-Treated Children and Adolescents: A Practical Approach.","authors":"Rae-Ellen W Kavey","doi":"10.1007/s11883-024-01239-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>This paper reviews the existing literature on statin-related myopathy in children and adolescents, to inform development of a practical management approach.</p><p><strong>Recent findings: </strong>Reports of statin treatment in the pediatric population revealed no evidence of muscle pathology, with asymptomatic elevation of creatine kinase(CK) levels and symptoms of muscle pain without CK elevation seen equally in subjects and controls in RCTs. By contrast, rare cases of rhabdomyolysis have now been documented in statin-treated children; this serious problem had never been previously reported. Statin-induced myopathy is rare in childhood so routine monitoring of CK levels is unnecessary in asymptomatic patients, reserved for those with muscle pain. Rare case reports of rhabdomyolysis in statin-treated children and adolescents suggest that parent and patient education on symptoms of adverse statin effects should include immediate physician contact with the appearance of dark urine, with or without muscle pain.</p>","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":" ","pages":"683-692"},"PeriodicalIF":5.7000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Atherosclerosis Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11883-024-01239-x","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/24 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose of review: This paper reviews the existing literature on statin-related myopathy in children and adolescents, to inform development of a practical management approach.
Recent findings: Reports of statin treatment in the pediatric population revealed no evidence of muscle pathology, with asymptomatic elevation of creatine kinase(CK) levels and symptoms of muscle pain without CK elevation seen equally in subjects and controls in RCTs. By contrast, rare cases of rhabdomyolysis have now been documented in statin-treated children; this serious problem had never been previously reported. Statin-induced myopathy is rare in childhood so routine monitoring of CK levels is unnecessary in asymptomatic patients, reserved for those with muscle pain. Rare case reports of rhabdomyolysis in statin-treated children and adolescents suggest that parent and patient education on symptoms of adverse statin effects should include immediate physician contact with the appearance of dark urine, with or without muscle pain.
综述目的：本文回顾了有关儿童和青少年他汀相关肌病的现有文献，为制定切实可行的管理方法提供参考：关于他汀类药物在儿童人群中的治疗的报告显示，没有肌肉病变的证据，无症状的肌酸激酶（CK）水平升高和无肌酸激酶升高的肌肉疼痛症状在受试者和对照组中同样可见。与此相反，他汀类药物治疗的儿童中出现了罕见的横纹肌溶解症病例；这一严重问题以前从未报道过。他汀类药物诱发的肌病在儿童期很少见，因此对无症状的患者不必进行 CK 水平的常规监测，只需监测肌肉疼痛患者的 CK 水平。他汀类药物治疗的儿童和青少年发生横纹肌溶解症的罕见病例报告表明，在对家长和患者进行他汀类药物不良反应症状的教育时，应包括在出现深色尿液、伴有或不伴有肌肉疼痛时立即联系医生。
期刊介绍：
The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment.
We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.
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