Substantiating the Short Burst Duration in Cortical Myoclonus.

IF 7.4 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2024-09-24 DOI:10.1002/mds.29990

Sterre van der Veen, Amber Maliepaard, Madelein van der Stouwe, Jelle Dalenberg, Inge Tuitert, Jan Willem J Elting, Marina A J Tijssen

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引用次数: 0

Abstract

Background: Myoclonus is characterized by involuntary, shock-like movements, of which cortical (CM) and non-cortical myoclonus (NCM) are most common. Electrophysiology can help differentiate between these subtypes; however, the diagnostic value of several features is largely unknown.

Objective: This study aims to determine the diagnostic value of the burst duration in distinguishing CM and NCM.

Methods: We manually identified the burst duration of 8 patients with CM, confirmed by electromyography-electroencephalography registration or somatosensory-evoked potentials, and 19 patients with NCM, suspected due to a myoclonus-dystonia phenotype (MYC/DYT-SGCE positive and negative).

Results: The sensitivity and specificity were calculated to assess the diagnostic value. The burst duration of CM (31.1 ms) was significantly shorter than that of NCM (56.7 ms), with a sensitivity of 100% and a specificity of 89.5% at a threshold of 45.0 ms. A minimum of 10 randomly selected bursts were sufficient for reliable diagnostic accuracy.

Conclusion: The burst duration seems a valuable supportive diagnostic criterion for distinguishing CM and NCM. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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证实皮层肌阵挛的短爆发持续时间

背景：肌阵挛的特征是不自主的冲击样运动，其中皮质肌阵挛（CM）和非皮质肌阵挛（NCM）最为常见。电生理学有助于区分这些亚型；然而，一些特征的诊断价值在很大程度上还不为人所知：本研究旨在确定爆发持续时间在区分 CM 和 NCM 方面的诊断价值：方法：我们对 8 名经肌电图-脑电图登记或体感诱发电位证实的 CM 患者和 19 名因肌阵挛-肌张力障碍表型（MYC/DYT-SGCE 阳性和阴性）而被怀疑的 NCM 患者的爆发持续时间进行了人工鉴定：计算灵敏度和特异性以评估诊断价值。在阈值为 45.0 毫秒时，CM 的爆发持续时间（31.1 毫秒）明显短于 NCM（56.7 毫秒），灵敏度为 100%，特异性为 89.5%。至少 10 次随机选择的脉冲串足以获得可靠的诊断准确性：结论：脉冲串持续时间似乎是区分 CM 和 NCM 的重要辅助诊断标准。© 2024 The Author(s).运动障碍》由 Wiley Periodicals LLC 代表国际帕金森和运动障碍协会出版。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.