[Therapeutic effect of vitamin D supplementation in mexican patients with allergic rhinitis].

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) Pub Date : 2024-06-30 DOI:10.29262/ram.v71i2.1282

Daniela Rivero-Yeverino, Jonathan Higgins Payan-Diaz, Aída Inés López-García, José Sergio Papaqui-Tapia, Chrystopherson Gengyny Caballero-López, Juan Jesús Ríos-López, Carlos David López-Romero, Johav Yael Sánchez-Villalobos, Elisa Ortega Jordá-Rodríguez, Armando Álvarez-Rivera, Erika Villada-Villada

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Abstract

Objetives: To evaluate the impact of cholecalciferol (D₃) supplementation using clinical and paraclinical variables in patients with RA and vitamin D insufficiency and deficiency.

Methods: A randomized, double-blind, placebo-controlled study included patients from 5 to 40 years with a diagnosis of RA and vitamin D insufficiency and deficiency. They were supplemented for 8 weeks with 4000 or 5000 IU, depending on age. Total nasal symptoms score (TNSS) was measured monthly and 25(OH)D₃ levels at baseline and at the end of the study.

Results: A total of 31 patients were included, with a mean age of 18.19 years. In the active group, there was a significant improvement in symptomatology with respect to the TNSS score and an increase in serum vitamin D levels (p < 0.01). There were no adverse reactions with cholecalciferol or placebo.

Conclusions: Supplementing patients with vitamin D₃, at the evaluated dose, together with conventional treatent for allergic rhinitis results in symptoms and quality of life improvement in patients with this disease.

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[补充维生素 D 对墨西哥过敏性鼻炎患者的治疗效果]。

目的利用临床和辅助临床变量评估补充胆钙化醇（D₃）对伴有维生素D不足和缺乏的RA患者的影响：一项随机、双盲、安慰剂对照研究纳入了5至40岁、诊断为RA和维生素D不足或缺乏的患者。根据患者的年龄，为其补充 4000 或 5000 IU，为期 8 周。每月测量鼻腔症状总评分（TNSS），并在基线和研究结束时测量 25（OH）D₃水平：共纳入 31 名患者，平均年龄为 18.19 岁。在积极治疗组中，TNSS 评分和血清维生素 D 水平均有显著改善（P < 0.01）。胆钙化醇或安慰剂均未出现不良反应：结论：按照评估的剂量补充维生素 D₃，同时采用传统的过敏性鼻炎治疗方法，可改善过敏性鼻炎患者的症状和生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

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