Multiple Abdominal Desmoplastic Small Round-Cell Tumors Treated With Fan Beam Computed Tomography-Guided Adaptive Radiotherapy (FBCT-gART): A Case Report.

IF 1 Q3 MEDICINE, GENERAL & INTERNAL

Cureus Pub Date : 2024-09-20 eCollection Date: 2024-09-01 DOI:10.7759/cureus.69785

Haohua Wang, Xiang Zhang, Jinbo Yue

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Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive soft tissue tumor that predominantly affects the abdominal and pelvic regions of adolescent males. This case report presents our clinical experience of treating a 33-year-old male with multifocal peritoneal DSRCT using fan beam computed tomography-guided adaptive radiotherapy (FBCT-gART). The patient presented with abdominal pain and was diagnosed with DSRCT following imaging and biopsy. Despite initial treatment with surgery, chemotherapy, and targeted therapy, the patient experienced multifocal peritoneal recurrence. Due to the considerable mobility of the abdominal tumors and the associated risks to adjacent critical organs, the patient underwent daily online FBCT-gART. The prescribed dose regimen was 54 Gy delivered in 27 fractions at 2 Gy per fraction; however, the patient ultimately received only 25 treatments for personal reasons. This case report evaluates the technical workflow of using FBCT-gART for DSRCT and discusses its dosimetric advantages over non-adaptive radiotherapy.

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用扇形光束计算机断层扫描引导的自适应放疗（FBCT-gART）治疗多发性腹部去势小圆细胞瘤：病例报告。

脱屑性小圆形细胞瘤（DSRCT）是一种罕见的高侵袭性软组织肿瘤，主要侵犯青少年男性的腹部和盆腔。本病例报告介绍了我们采用扇形束计算机断层扫描引导下的自适应放射治疗（FBCT-gART）治疗一名患有多灶性腹膜 DSRCT 的 33 岁男性患者的临床经验。患者因腹痛就诊，经造影和活检确诊为 DSRCT。尽管最初接受了手术、化疗和靶向治疗，但患者仍出现多灶性腹膜复发。由于腹部肿瘤具有相当大的流动性，且对邻近重要器官存在相关风险，患者接受了每日在线 FBCT-gART 治疗。规定的剂量方案为 54 Gy，分 27 次给药，每次 2 Gy；但由于个人原因，患者最终只接受了 25 次治疗。本病例报告评估了使用 FBCT-gART 进行 DSRCT 的技术工作流程，并讨论了其与非适应性放疗相比在剂量学方面的优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cureus

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