Faecal intestinal permeability and intestinal inflammatory markers in older adults with age-related disorders: A systematic review and meta-analysis

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-09-19 DOI:10.1016/j.arr.2024.102506

Nurul Izzati Ahmad Fadzuli , Siong Meng Lim , Chin Fen Neoh , Abu Bakar Abdul Majeed , Maw Pin Tan , Hui Min Khor , Ai Huey Tan , Kalavathy Ramasamy

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Abstract

This systematic review and meta-analysis appraised previous findings to uncover potential faecal intestinal permeability and intestinal inflammatory markers in older adults. A comprehensive literature search led to the identification of ten eligible studies with findings of potential faecal intestinal permeability (zonulin and alpha-1-antitrypsin) and intestinal inflammatory markers [calprotectin, lactoferrin and neutrophil gelatinase-associated lipocalin (NGAL)]. Most of the cases (n > 2) [Parkinson’s disease (PD) and Alzheimer’s disease (AD)] exhibited higher faecal alpha-1-antitrypsin, zonulin and calprotectin levels. The present meta-analysis confirmed significantly higher faecal alpha-1-antitrypsin in older persons with PD compared to non-PD [MD = 22.92 mg/dL; 95 % CI = 14.02–31.81, p < 0.00001; I² = 0 % (p = 0.73)]. There was, however, no significant difference in faecal zonulin between PD and non-PD individuals [MD = 26.88 ng/mL; 95 % CI = −29.26–83.01, p = 0.35; I² = 94 % (p < 0.0001)]. Meanwhile, faecal calprotectin was higher in older adults with GI symptoms, multiple system atrophy (MSA) or PD than the healthy controls [MD = 9.51 μg/g; 95 % CI = 0.07–18.95, p = 0.05; I² = 84 % (p < 0.00001)]. Altogether, faecal calprotectin appears to be a potential intestinal inflammatory marker whereas previous findings on faecal alpha-1-antitrypsin as an intestinal permeability marker remain limited and require further validation.

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患有老年性疾病的老年人的粪便肠道渗透性和肠道炎症标志物：系统回顾和荟萃分析。

本系统综述和荟萃分析对以往的研究结果进行了评估，以发现老年人潜在的粪便肠道渗透性和肠道炎症标志物。通过全面的文献检索，确定了十项符合条件的研究，这些研究发现了潜在的粪便肠道通透性（zonulin 和 alpha-1-抗胰蛋白酶）和肠道炎症标记物[钙蛋白、乳铁蛋白和中性粒细胞明胶酶相关脂联素（NGAL）]。大多数病例（n > 2）[帕金森病（PD）和阿尔茨海默病（AD）]的粪便中α-1-抗胰蛋白酶、zonulin 和钙蛋白水平较高。本荟萃分析证实，与非帕金森病患者相比，帕金森病老年人粪便中的α-1-抗胰蛋白酶水平明显更高[MD = 22.92mg/dL; 95% CI = 14.02 to 31.81, p < 0.00001; I2 = 0% (p = 0.73)]。然而，腹水症患者和非腹水症患者粪便中的zonulin没有明显差异[MD = 26.88ng/mL; 95% CI = -29.26 to 83.01, p = 0.35; I2 = 94% (p < 0.0001)]。同时，与健康对照组相比，有消化道症状、多系统萎缩（MSA）或腹膜后疾病的老年人的粪便钙蛋白更高[MD = 9.51μg/g；95% CI = 0.07 to 18.95，p = 0.05；I2 = 84% (p < 0.00001)]。总之，粪便钙蛋白似乎是一种潜在的肠道炎症标志物，而之前关于粪便α-1-抗胰蛋白酶作为肠道通透性标志物的研究结果仍然有限，需要进一步验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.