Association between pulse wave velocity and white matter hyperintensities among older adults: A meta-analysis of cross-sectional and longitudinal studies

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-09-18 DOI:10.1016/j.arr.2024.102501

Celia Álvarez-Bueno , María Medrano , Maribel Lucerón-Lucas-Torres , Iris Otero-Luis , Samuel López-López , Carla Geovanna Lever-Megina , Iván Cavero-Redondo

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引用次数: 0

Abstract

Background

Higher levels of pulse wave velocity (PWV) have been related with the presence of small vessel disease that could damage the brain, in which white matter hyperintensities (WMH) could be presented as consequence. This meta-analysis aims to examine the cross-sectional and longitudinal associations between PWV and the presence of WMH among older adults.

Methods

We searched PubMed, Scopus, and WOS until June 2024. Pooled Odds Ratio (p-OR) were estimated for the cross-sectional and longitudinal associations between PWV and WMH. In addition, we explored whether this associations could be modified by type of PWV measurement and study and sample characteristics.

Results

The p-OR between PWV and WMH was 1.16 (95 % CI, 1.10–1.22) for the cross-sectional and 1.07 (95 %, 1.00–1.15) for the longitudinal association. Similar figures were found by type of PWV measurement and no one of the explored characteristics modified this associations.

Conclusions

This meta-analysis revealed that the presence in and the long-term development of WMHs among older adults are more likely among those with elevated PWV.

查看原文本刊更多论文

脉搏波速度与老年人白质高密度之间的关系：横断面和纵向研究的荟萃分析。

背景：脉搏波速度（PWV）水平较高与可能损害大脑的小血管疾病有关，白质高密度（WMH）可能是小血管疾病的后果。本荟萃分析旨在研究脉搏波速度与老年人白质增厚之间的横向和纵向关系：方法：我们检索了 PubMed、Scopus 和 WOS，直至 2024 年 6 月。方法：我们检索了截至 2024 年 6 月的 PubMed、Scopus 和 WOS，并估算了脉搏波速度与 WMH 之间的横向和纵向关联的汇总比值（p-OR）。此外，我们还探讨了这种关联是否会因脉搏波速度测量类型以及研究和样本特征而改变：脉搏波速度与 WMH 之间的 p-OR 分别为 1.16（95% CI，1.10 至 1.22）和 1.07（95%，1.00 至 1.15）。脉搏波速度的测量类型也显示出类似的数据，而且所探讨的特征中没有一项会改变这种关联：这项荟萃分析表明，脉搏波速度升高的老年人更有可能出现 WMHs，并有可能长期发展为 WMHs。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.