A method for calculating the grand average of a set of auditory brain-stem responses.

Abstract

To calculate a grand average waveform for a set of auditory brain-stem responses (ABRs), no generally accepted method exists. Here, we evaluate a new method using temporal adjustment of the underlying ABRs. Compared to a method without temporal adjustment, the new method results in higher amplitudes of the individual waves in the grand average. The grand average produced by the method better represents the group mean wave-amplitudes because it reduces smearing of the individual waves caused by inter-subject latency variability.