Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study

IF 3.9 2区医学 Q1 PEDIATRICS

Journal of Pediatrics Pub Date : 2024-09-19 DOI:10.1016/j.jpeds.2024.114322

Lindsay M. Thomson MD , Sierra Niemiec MS , Christopher A. Mancuso PhD , Ludmila Khailova MS , Eiman Ali MBBS , Aneesa Syed BS, MBA , Kelly R. Wolfe PhD , Jack Zakrzewski MD , Matthew Stone MD, PhD , Robert Hyslop RN , Benjamin S. Frank MD , Jesse A. Davidson MD, MPH, MSc

引用次数: 0

Abstract

This nested case-control study identified broad dysregulation of the circulating proteome in neonates receiving postoperative extracorporeal membrane oxygenation support after congenital heart disease surgery, including differential responses in those not surviving to hospital discharge. Tissue hypoxia and mitochondrial-associated proteins may represent novel candidate biomarkers for poor extracorporeal membrane oxygenation outcomes.

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先天性心脏病手术后接受体外膜氧合的新生儿循环蛋白质组的破坏：一项嵌套病例对照研究。

这项巢式病例对照研究发现，在先天性心脏病手术后接受体外膜氧合（ECMO）支持的新生儿中，循环蛋白质组出现了广泛的失调，包括那些未能存活到出院的新生儿的不同反应。组织缺氧和线粒体相关蛋白可能是导致 ECMO 不良后果的新型候选生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pediatrics 医学-小儿科

CiteScore

6.00

自引率

2.00%

发文量

696

审稿时长

31 days

期刊介绍： The Journal of Pediatrics is an international peer-reviewed journal that advances pediatric research and serves as a practical guide for pediatricians who manage health and diagnose and treat disorders in infants, children, and adolescents. The Journal publishes original work based on standards of excellence and expert review. The Journal seeks to publish high quality original articles that are immediately applicable to practice (basic science, translational research, evidence-based medicine), brief clinical and laboratory case reports, medical progress, expert commentary, grand rounds, insightful editorials, “classic” physical examinations, and novel insights into clinical and academic pediatric medicine related to every aspect of child health. Published monthly since 1932, The Journal of Pediatrics continues to promote the latest developments in pediatric medicine, child health, policy, and advocacy. Topics covered in The Journal of Pediatrics include, but are not limited to: General Pediatrics Pediatric Subspecialties Adolescent Medicine Allergy and Immunology Cardiology Critical Care Medicine Developmental-Behavioral Medicine Endocrinology Gastroenterology Hematology-Oncology Infectious Diseases Neonatal-Perinatal Medicine Nephrology Neurology Emergency Medicine Pulmonology Rheumatology Genetics Ethics Health Service Research Pediatric Hospitalist Medicine.