Therapeutic potential of cannabis for surgical wound healing in rats.

IF 0.6 4区农林科学 Q3 VETERINARY SCIENCES

Veterinarni Medicina Pub Date : 2024-08-16 eCollection Date: 2024-08-01 DOI:10.17221/21/2024-VETMED

Gokhan Dogukan Akarsu, Rukiye Hobek Akarsu

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引用次数: 0

Abstract

This study was conducted to evaluate the wound-healing activities of a Cannabis sativa L. plant extract and cannabidiol on incision wounds. An incision was created and sutured in rats under anaesthesia. Routine wound care procedures were applied for 10 days, followed by histological wound examinations. The cellular bioactivities of the hemp extract and CBD were assessed for MCP-1, EGF, BFGF, IL-8, and COL-1 using ELISA on the rat skin wound healing activity. A one-way ANOVA was used for the data analysis. The EGF values in the plasma were similar in the povidone-iodine, hemp seed oil, and hemp essential oil groups (P > 0.05). However, the EGF levels were lower in the CBD group compared to the other groups (P < 0.001, P < 0.005). The MCP-1 values in the hemp seed oil, hemp essential oil, and CBD were similar (P > 0.05), whereas povidone iodine exhibited lower MCP-1 levels compared to the other groups (P < 0.001, P < 0.005). It was determined that the plasma BFGF, IL-8, and COL 1 values of the groups were similar (P > 0.05). To our knowledge, this study is the first to evaluate the effects of CBD, seed oil, and hemp leaf extract on incision wound healing. It demonstrates that hemp extract holds greater potential benefits for wound healing compared to CBD.

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大麻对大鼠手术伤口愈合的治疗潜力。

本研究旨在评估大麻植物提取物和大麻二酚对切口伤口的愈合活性。大鼠在麻醉状态下被切开并缝合伤口。常规伤口护理程序持续 10 天，然后进行伤口组织学检查。使用 ELISA 方法评估了大麻提取物和 CBD 在大鼠皮肤伤口愈合活动中的细胞生物活性，包括 MCP-1、EGF、BFGF、IL-8 和 COL-1。数据分析采用单因素方差分析。聚维酮碘组、大麻籽油组和大麻精油组血浆中的 EGF 值相似（P > 0.05）。然而，与其他组相比，大麻籽油组的 EGF 水平较低（P < 0.001，P < 0.005）。大麻籽油、大麻精油和 CBD 组的 MCP-1 值相似（P > 0.05），而聚维酮碘组的 MCP-1 水平低于其他组（P < 0.001，P < 0.005）。经测定，各组的血浆 BFGF、IL-8 和 COL 1 值相似（P > 0.05）。据我们所知，这项研究是首次评估 CBD、种子油和大麻叶提取物对切口伤口愈合的影响。它表明，与 CBD 相比，大麻提取物对伤口愈合具有更大的潜在益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinarni Medicina Veterinary Sciences-兽医学

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

18-36 weeks

期刊介绍： The journal Veterinarni Medicina publishes in English original papers, short communications, critical reviews and case reports from all fields of veterinary and biomedical sciences.