Viral imitation is the sincerest form of epigenetic flattery.

IF 3.1 3区 生物学 Q3 CELL BIOLOGY
Julian R Smith, Angela A Arellano, Daphne C Avgousti
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引用次数: 0

Abstract

Viruses use multiple strategies to successfully generate progeny and overcome host defenses. In recent years, it has become increasingly evident that epigenetic mechanisms of host gene regulation are vulnerable to viral manipulation. In the form of histone mimicry, viral invasion of host chromatin is a striking example of how viruses have evolved to invade every aspect of cellular function for viral benefit. In this perspective, we will review how three viruses-influenza A, SARS-CoV-2, and Cotesia plutellae bracovirus-use histone mimicry to promote viral success through immune evasion. These examples highlight the importance of this burgeoning field and point toward the wealth of knowledge we have yet to uncover.

病毒式模仿是表观遗传学最真诚的奉承。
病毒利用多种策略成功地产生后代并克服宿主防御。近年来,宿主基因调控的表观遗传机制很容易受到病毒的操纵,这一点已变得越来越明显。病毒以组蛋白模仿的形式入侵宿主染色质,是病毒如何进化到入侵细胞功能的各个方面以获得病毒利益的一个突出例子。在这一视角中,我们将回顾三种病毒--甲型流感、SARS-CoV-2 和 Cotesia plutellae bracovirus--是如何利用组蛋白拟态通过免疫逃避来促进病毒成功的。这些例子凸显了这一新兴领域的重要性,并指出了我们尚未发现的丰富知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular Biology of the Cell
Molecular Biology of the Cell 生物-细胞生物学
CiteScore
6.00
自引率
6.10%
发文量
402
审稿时长
2 months
期刊介绍: MBoC publishes research articles that present conceptual advances of broad interest and significance within all areas of cell, molecular, and developmental biology. We welcome manuscripts that describe advances with applications across topics including but not limited to: cell growth and division; nuclear and cytoskeletal processes; membrane trafficking and autophagy; organelle biology; quantitative cell biology; physical cell biology and mechanobiology; cell signaling; stem cell biology and development; cancer biology; cellular immunology and microbial pathogenesis; cellular neurobiology; prokaryotic cell biology; and cell biology of disease.
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