Effect of Age on the Pharmacokinetics of Marbofloxacin Following Intravenous Administration in Calves.

IF 1.5 4区农林科学 Q3 PHARMACOLOGY & PHARMACY

Journal of veterinary pharmacology and therapeutics Pub Date : 2024-09-17 DOI:10.1111/jvp.13483

Orhan Corum, Murat Yuksel, Devran Coskun, Duygu Durna Corum, Serafettin Kartal, Mustafa Cellat, Kamil Uney

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Abstract

The aim of this study was to compare the pharmacokinetics of marbofloxacin after intravenous (IV) administration of a single dose of 10 mg/kg to calves of different ages. The study was carried on 1- (n = 6), 2- (n = 6), and 4-month-old (n = 6) Montofon calves. Plasma concentrations of marbofloxacin were measured using HPLC, and pharmacokinetic data were calculated by non-compartmental analysis. The elimination half-life (t_1/2ʎz), volume of distribution at steady state (V_dss), total clearance (Cl_T), and area under the concentration-versus time curve (AUC_0-∞) values of marbofloxacin in 1-month-old calves were 10.62 h, 1.03 L/kg, 0.08 L/h/kg, and 127.90 h*μg/mL, respectively. While the t_1/2ʎz (from 10.62 to 3.36 h) and AUC_0-∞ (from 127.90 to 47.35 h*μg/mL) decreased in parallel with the age of the calves, Cl_T (from 0.08 to 0.21 L/h/kg) increased. The V_dss of marbofloxacin was higher in 1- and 2-month-old calves compared to 4-month-old calves. After IV administration of marbofloxacin at a dose of 10 mg/kg, an ƒAUC_0-24/MIC₉₀ ratio of ≥ 125 was obtained for bacteria with MIC₉₀ values of ≤ 0.60, ≤ 0.39 and ≤ 0.27 μg/mL in 1-, 2-, and 4-month-old calves, respectively. These results show that the antibacterial effect of marbofloxacin, which has concentration-dependent activity, decreases due to age-related pharmacokinetic changes and that the 10 mg/kg dose should be reviewed according to the MIC₉₀ value of the bacteria.

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年龄对犊牛静脉注射马勃沙星药代动力学的影响

本研究的目的是比较不同年龄的小牛静脉注射单剂量 10 毫克/千克的马拉氧氟沙星的药代动力学。研究对象为 1 个月大（6 头）、2 个月大（6 头）和 4 个月大（6 头）的蒙托邦小牛。采用高效液相色谱法测定了马拉氧氟沙星的血浆浓度，并通过非室分析法计算了药代动力学数据。1 月龄犊牛的消除半衰期 (t1/2ʎz)、稳态分布容积 (Vdss)、总清除率 (ClT) 和浓度-时间曲线下面积 (AUC0-∞) 值分别为 10.62 h、1.03 L/kg、0.08 L/h/kg 和 127.90 h*μg/mL。虽然 t1/2ʎz（从 10.62 到 3.36 h）和 AUC0-∞（从 127.90 到 47.35 h*μg/mL）随着犊牛年龄的增长而下降，但 ClT（从 0.08 到 0.21 L/h/kg）却增加了。与 4 个月大的犊牛相比，1 个月大和 2 个月大的犊牛的马拉氧沙星 Vdss 较高。静脉注射 10 mg/kg 剂量的马拉氧氟沙星后，1 个月、2 个月和 4 个月犊牛体内细菌的 MIC90 值分别为 ≤ 0.60、≤ 0.39 和 ≤ 0.27 μg/mL 时，ƒAUC0-24/MIC90 比率≥125。这些结果表明，具有浓度依赖性的马拉氧氟沙星的抗菌效果会因年龄相关的药代动力学变化而降低，因此应根据细菌的 MIC90 值重新考虑 10 mg/kg 的剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of veterinary pharmacology and therapeutics 农林科学-兽医学

CiteScore

3.10

自引率

15.40%

发文量

审稿时长

8-16 weeks

期刊介绍： The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.