Acute Cardiovascular Responses to the 100-Mile Western States Endurance Run.

IF 3.3 3区医学 Q1 PHYSIOLOGY

Journal of applied physiology Pub Date : 2024-09-19 DOI:10.1152/japplphysiol.00412.2024

Matthew C Babcock, Omar B El-Kurd, James R Bagley, Braxton A Linder, Nina L Stute, Soolim Jeong, Joseph D Vondrasek, Joseph C Watso, Austin T Robinson, Gregory J Grosicki

{"title":"Acute Cardiovascular Responses to the 100-Mile Western States Endurance Run.","authors":"Matthew C Babcock, Omar B El-Kurd, James R Bagley, Braxton A Linder, Nina L Stute, Soolim Jeong, Joseph D Vondrasek, Joseph C Watso, Austin T Robinson, Gregory J Grosicki","doi":"10.1152/japplphysiol.00412.2024","DOIUrl":null,"url":null,"abstract":"Ultramarathon participation is growing in popularity and exposes runners to unique stressors including extreme temperatures, high altitude, and exceedingly long exercise duration. However, the acute effects of ultramarathon participation on the cardiovascular system are not well understood.Purpose: To determine the acute effects of trail ultramarathon participation on central artery stiffness and hemodynamics.Methods: Forty-one participants (9F, 32M) participating in the 2023 Western States Endurance Run underwent measures of carotid-femoral pulse wave velocity (cf-PWV) and pulse wave analysis pre- and <1h post-race. Subendocardial viability ratio (SEVR) was calculated from central blood pressure (BP) waveforms. Serum was analyzed for creatine kinase (CK) activity as a measure of muscle damage. Normally distributed data are presented as mean±SD and non-normally distributed data are presented as median (interquartile range).Results: Runners were middle-aged and generally lean (age=44±9 y, BMI=22.7±1.8 kg●m-2). There was no difference in cf-PWV from pre- to post-race (pre=6.4±1.0, post=6.2±0.85 m/s, p=0.104), a finding that persisted after adjusting for mean arterial pressure (p=0.563). Systolic and diastolic BP were lower post-race (pre=129/77±9/7, post=122/74±10/8 mmHg, ps<0.001). Augmentation index (AIx; pre=17.3±12.2, post=6.0±13.7%, p<0.001), AIx normalized to a heart rate of 75bpm (p=0.043), reflection magnitude (pre=55.5(49.0-60.8), post=45.5(41.8-48.8) %, p<0.001), and SEVR (pre=173.0(158.0-190.0), post=127.5(116.5-145.8) %, p<0.001) were reduced post-race. CK increased markedly from pre- to post-race (pre=111(85-162), post=11,973(5,049-17,954) U/L, p<0.001).Conclusions: Completing a 161-km trail ultramarathon does not affect central arterial stiffness and acutely reduces BP despite eliciting profound muscle damage. However, the reduced post-race SEVR suggests a short-term mismatch between myocardial work and coronary artery perfusion.","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of applied physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1152/japplphysiol.00412.2024","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Ultramarathon participation is growing in popularity and exposes runners to unique stressors including extreme temperatures, high altitude, and exceedingly long exercise duration. However, the acute effects of ultramarathon participation on the cardiovascular system are not well understood.

Purpose: To determine the acute effects of trail ultramarathon participation on central artery stiffness and hemodynamics.

Methods: Forty-one participants (9F, 32M) participating in the 2023 Western States Endurance Run underwent measures of carotid-femoral pulse wave velocity (cf-PWV) and pulse wave analysis pre- and <1h post-race. Subendocardial viability ratio (SEVR) was calculated from central blood pressure (BP) waveforms. Serum was analyzed for creatine kinase (CK) activity as a measure of muscle damage. Normally distributed data are presented as mean±SD and non-normally distributed data are presented as median (interquartile range).

Results: Runners were middle-aged and generally lean (age=44±9 y, BMI=22.7±1.8 kg●m^-2). There was no difference in cf-PWV from pre- to post-race (pre=6.4±1.0, post=6.2±0.85 m/s, p=0.104), a finding that persisted after adjusting for mean arterial pressure (p=0.563). Systolic and diastolic BP were lower post-race (pre=129/77±9/7, post=122/74±10/8 mmHg, ps<0.001). Augmentation index (AIx; pre=17.3±12.2, post=6.0±13.7%, p<0.001), AIx normalized to a heart rate of 75bpm (p=0.043), reflection magnitude (pre=55.5(49.0-60.8), post=45.5(41.8-48.8) %, p<0.001), and SEVR (pre=173.0(158.0-190.0), post=127.5(116.5-145.8) %, p<0.001) were reduced post-race. CK increased markedly from pre- to post-race (pre=111(85-162), post=11,973(5,049-17,954) U/L, p<0.001).

Conclusions: Completing a 161-km trail ultramarathon does not affect central arterial stiffness and acutely reduces BP despite eliciting profound muscle damage. However, the reduced post-race SEVR suggests a short-term mismatch between myocardial work and coronary artery perfusion.

查看原文本刊更多论文

西部各州 100 英里耐力跑的急性心血管反应。

参加超级马拉松比赛的人越来越多，这使跑步者面临独特的压力，包括极端温度、高海拔和超长的运动时间。目的：确定参加越野超级马拉松对中央动脉僵化和血液动力学的急性影响：41名参加2023年西部各州耐力跑的选手（9名女性，32名男性）接受了颈动脉-股动脉脉搏波速度（cf-PWV）测量和脉搏波分析：跑步者均为中年人，普遍偏瘦（年龄=44±9 y，体重指数=22.7±1.8 kg●m-2）。cf-PWV在赛前和赛后没有差异（赛前=6.4±1.0，赛后=6.2±0.85 m/s，p=0.104），在调整平均动脉压后仍有差异（p=0.563）。赛后收缩压和舒张压均有所降低（赛前=129/77±9/7，赛后=122/74±10/8 mmHg，ps结论：完成 161 公里的越野超级马拉松不会影响中心动脉僵化，尽管会造成严重的肌肉损伤，但却能迅速降低血压。然而，赛后 SEVR 的降低表明心肌工作和冠状动脉灌注之间存在短期不匹配。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of applied physiology 医学-生理学

CiteScore

6.00

自引率

9.10%

发文量

296

审稿时长

2-4 weeks

期刊介绍： The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.