High-grade endometrial stromal sarcoma with BCOR rearrangements: clinicopathological analysis of five cases and literature reviews - an extension in understanding of morphological characteristics.

IF 1.1 Q4 ONCOLOGY

International journal of clinical and experimental pathology Pub Date : 2024-08-15 eCollection Date: 2024-01-01 DOI:10.62347/GDKO4005

Xuan Zuo, Wei Jiang, Yan-Mei He, Wei Kuang, Lei Li

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Abstract

Five cases of FISH verified BCOR rearranged high-grade endometrial stromal sarcoma were retrospectively analyzed. The patient age ranged from 33 to 65 years (median, 48.4 years). Most patients presented with irregular vaginal bleeding (3/5) and uterus mass (2/5). Only one patient developed an abdominal wall metastasis and other patients remained in good condition during the follow-up. Pathological findings revealed that the tumors exhibited morphological diversity in terms of cell shape, arrangement pattern and tumor stroma, compared to previous summarized histology of BCOR rearranged high-grade endometrial stromal sarcoma. Detailed description of such morphology changes expanded our understanding of the histology of BCOR rearranged high-grade endometrial stromal sarcoma. Due to the non-specificity of morphology in such malignancies, molecular testing is needed for confirmation in all patients.

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伴有BCOR重排的高级别子宫内膜间质肉瘤：五例病例的临床病理分析和文献综述--扩展了对形态特征的认识。

我们对五例经FISH验证的BCOR重排高级别子宫内膜间质肉瘤进行了回顾性分析。患者年龄从 33 岁到 65 岁不等（中位 48.4 岁）。大多数患者表现为不规则阴道出血（3/5）和子宫肿块（2/5）。只有一名患者出现腹壁转移，其他患者在随访期间状况良好。病理结果显示，与之前总结的 BCOR 重排高级别子宫内膜间质肉瘤组织学相比，肿瘤在细胞形状、排列模式和肿瘤基质方面表现出形态多样性。对这些形态变化的详细描述拓展了我们对 BCOR 重排高级别子宫内膜间质肉瘤组织学的理解。由于形态学在此类恶性肿瘤中的非特异性，因此需要对所有患者进行分子检测来确认。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of clinical and experimental pathology ONCOLOGY-PATHOLOGY

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0.00%

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审稿时长

1 months

期刊介绍： The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.