Rates and predictors for sustained ventricular tachycardia in patients with cardiac sarcoidosis and AV block as first cardiac presentation: implications for device implantation.
Borislav Dinov, Carsten Henfling, Hans Ebbinghaus, Konrad Latuscynski, Ingo Paetsch, Cosima Jahnke, Samuel Sossalla, Ulrich Laufs, Laura Ueberham
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引用次数: 0
Abstract
Background: Atrioventricular block (AVB) is a frequent initial presentation of cardiac sarcoidosis (CS), but dangerous ventricular arrhythmias (VA) can occur. Despite the scarcity of data, guidelines recommend ICD rather than a pacemaker implantation whenever a device is needed.
Objective: In this study, we aimed to establish predictors for sustained VA in patients with CS presenting with pacing indication due to an AVB.
Methods: We prospectively enrolled 112 patients with CS. Excluding those with VA, 82 patients remained and were divided into 2 groups: 34 individuals with AVB as initial presentation and 48 with other symptoms as first presentation (OSF). Both groups were compared for clinical characteristics, rates of VA, LVAD implantation, heart transplantation and mortality.
Results: During follow-up, VA was detected in 50% in the AVB and 10.4% in the OSF group; P = 0.001. Death, LVAD implantation, heart transplantation occurred in 11.8% in AVB vs. 10.4% in the OSF; P = 0.847. Late gadolinium enhancement (LGE) was equally observed in both groups: 70% vs. 70.5%; P = 0.966, whereas more patients in the AVB group exhibited abnormal PET uptake: 86.2% vs. 54.3%; P = 0.007. In multivariate analysis, AVB (HR 25.15), RV LGE in CMR (HR 7.39) were predictors for VA occurrence, whereas the use of immunosuppressive therapy was associated with less VA (HR 4.3).
Conclusions: Patients with CS presenting with AVB have a high risk of sustained VA. Although immunosuppressive drugs may reduce the occurrence of VA, ICD implantation is reasonable, especially in case of right ventricular LGE.
期刊介绍:
HeartRhythm, the official Journal of the Heart Rhythm Society and the Cardiac Electrophysiology Society, is a unique journal for fundamental discovery and clinical applicability.
HeartRhythm integrates the entire cardiac electrophysiology (EP) community from basic and clinical academic researchers, private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our EP community.
The Heart Rhythm Society is the international leader in science, education, and advocacy for cardiac arrhythmia professionals and patients, and the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education, and optimal health care policies and standards.