Complex role of neutrophils in the tumor microenvironment: an avenue for novel immunotherapies.

IF 5.6 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Mao Zhang, Haokai Qin, Yingcheng Wu, Qiang Gao
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引用次数: 0

Abstract

Neutrophils, which originate from the bone marrow and are characterized by a segmented nucleus and a brief lifespan, have a crucial role in the body's defense against infections and acute inflammation. Recent research has uncovered the complex roles of neutrophils as regulators in tumorigenesis, during which neutrophils exhibit a dualistic nature that promotes or inhibits tumor progression. This adaptability is pivotal within the tumor microenvironment (TME). In this review, we provide a comprehensive characterization of neutrophil plasticity and heterogeneity, aiming to illuminate current research findings and discuss potential therapeutic avenues. By delineating the intricate interplay of neutrophils in the TME, this review further underscores the urgent need to understand the dual functions of neutrophils with particular emphasis on the anti-tumor effects to facilitate the development of effective therapeutic strategies against cancer.

中性粒细胞在肿瘤微环境中的复杂作用:新型免疫疗法的途径。
中性粒细胞起源于骨髓,具有分节核和短暂的生命周期,在机体抵御感染和急性炎症的过程中发挥着至关重要的作用。最近的研究发现,中性粒细胞在肿瘤发生过程中发挥着复杂的调节作用,中性粒细胞在肿瘤发生过程中表现出促进或抑制肿瘤发展的双重特性。这种适应性在肿瘤微环境(TME)中至关重要。在这篇综述中,我们对中性粒细胞的可塑性和异质性进行了全面描述,旨在阐明当前的研究成果并讨论潜在的治疗途径。通过描述中性粒细胞在肿瘤微环境中错综复杂的相互作用,本综述进一步强调了人们迫切需要了解中性粒细胞的双重功能,尤其是抗肿瘤作用,以促进开发有效的癌症治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancer Biology & Medicine
Cancer Biology & Medicine Medicine-Oncology
CiteScore
9.80
自引率
3.60%
发文量
1143
审稿时长
12 weeks
期刊介绍: Cancer Biology & Medicine (ISSN 2095-3941) is a peer-reviewed open-access journal of Chinese Anti-cancer Association (CACA), which is the leading professional society of oncology in China. The journal quarterly provides innovative and significant information on biological basis of cancer, cancer microenvironment, translational cancer research, and all aspects of clinical cancer research. The journal also publishes significant perspectives on indigenous cancer types in China.
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