Changed resting-state connectivity of anterior insular cortex affects subjective pain reduction after knee arthroplasty: A longitudinal study

IF 3.5 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2024-09-14 DOI:10.1016/j.brainresbull.2024.111073

Kai Ushio , Kazuyoshi Nakanishi , Atsuo Yoshino , Masahiro Takamura , Yuji Akiyama , Noboru Shimada , Kazuhiko Hirata , Masakazu Ishikawa , Atsuo Nakamae , Yukio Mikami , Yasumasa Okamoto , Nobuo Adachi

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引用次数: 0

Abstract

The mechanism of chronic knee osteoarthritis (OA) pain and postoperative pain due to knee arthroplasty has not been elucidated. This could be involved neuroplasticity in brain connectivity. To clarify the mechanism of chronic knee OA pain and postoperative pain, we examined the relationship between resting-state functional connectivity (rs-FC) and clinical measurements in knee OA before and after knee arthroplasty, focusing on rs-FCs with the anterior insular cortex (aIC) as the key region. Fifteen patients with knee OA underwent resting-state functional magnetic resonance imaging and clinical measurements shortly before and 6 months after knee arthroplasty, and 15 age- and sex-matched control patients underwent an identical protocol. Seed-to-voxel analysis was performed to compare the clinical measurements and changed rs-FCs, using the aIC as a seed region, between the preoperative and postoperative patients, as well as between the operative and control patients. In preoperative patients, rs-FCs of the aIC to the OFC, frontal pole, subcallosal area, and medial frontal cortex increased compared with those of the control patients. The strength of rs-FC between the left aIC and right OFC decreased before and after knee arthroplasty. The decrease in rs-FC between the left aIC and right OFC was associated with decreased subjective pain score. Our study showed a correlation between longitudinally changed rs-FC and clinical measurement before and after knee arthroplasty. Rs-FC between the aIC and OFC have the potential to elucidate the mechanisms of knee OA pain and postoperative pain due to knee arthroplasty.

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前岛叶皮层静息态连接的改变影响膝关节置换术后主观疼痛的减轻：一项纵向研究

慢性膝关节骨关节炎（OA）疼痛和膝关节置换术后疼痛的机制尚未阐明。这可能与大脑连接的神经可塑性有关。为了阐明慢性膝关节OA疼痛和术后疼痛的机制，我们研究了膝关节置换术前后膝关节OA静息态功能连接（rs-FC）与临床测量之间的关系，重点研究了以前部岛叶皮层（aIC）为关键区域的rs-FC。15名膝关节OA患者在膝关节置换术前不久和术后6个月接受了静息态功能磁共振成像和临床测量，15名年龄和性别匹配的对照组患者接受了相同的方案。以 aIC 为种子区域，对术前和术后患者以及手术患者和对照组患者的临床测量结果和 rs-FCs 变化进行了种子到象素分析比较。与对照组患者相比，术前患者的 aIC 至 OFC、额极、胼胝体下区和内侧额叶皮层的 rs-FCs 均有所增加。膝关节置换术前后，左侧 aIC 与右侧 OFC 之间的 rs-FC 强度下降。左侧aIC和右侧OFC之间rs-FC的降低与主观疼痛评分的降低有关。我们的研究表明，在膝关节置换术前后，rs-FC的纵向变化与临床测量之间存在相关性。aIC 和 OFC 之间的 rs-FC 有可能阐明膝关节 OA 疼痛和膝关节置换术后疼痛的机制。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.