Circadian disruption in cancer hallmarks: Novel insight into the molecular mechanisms of tumorigenesis and cancer treatment

IF 9.1 1区医学 Q1 ONCOLOGY

Cancer letters Pub Date : 2024-09-19 DOI:10.1016/j.canlet.2024.217273

Zhaokai Zhou , Ruiqi Zhang , Yuyuan Zhang , Yudi Xu , Ruizhi Wang , Shuang Chen , Yingying Lv , Yifeng Chen , Yuqing Ren , Peng Luo , Quan Cheng , Hui Xu , Siyuan Weng , Anning Zuo , Yuhao Ba , Shutong Liu , Xinwei Han , Zaoqu Liu

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引用次数: 0

Abstract

Circadian rhythms are 24-h rhythms governing temporal organization of behavior and physiology generated by molecular clocks composed of autoregulatory transcription-translation feedback loops (TTFLs). Disruption of circadian rhythms leads to a spectrum of pathologies, including cancer by triggering or being involved in different hallmarks. Clock control of phenotypic plasticity involved in tumorigenesis operates in aberrant dedifferentiating to progenitor-like cell states, generation of cancer stem cells (CSCs) and epithelial-to-mesenchymal transition (EMT) events. Circadian rhythms might act as candidates for regulatory mechanisms of cellular senescent and functional determinants of senescence-associated secretory phenotype (SASP). Reciprocal control between clock and epigenetics sheds light on post-transcriptional regulation of circadian rhythms and opens avenues for novel anti-cancer strategies. Additionally, disrupting circadian rhythms influences microbiota communities that could be associated with altered homeostasis contributing to cancer development. Herein, we summarize recent advances in support of the nexus between disruptions of circadian rhythms and cancer hallmarks of new dimensions, thus providing novel perspectives on potentially effective treatment approaches for cancer management.

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癌症特征中的昼夜节律紊乱：对肿瘤发生和癌症治疗分子机制的新见解。

昼夜节律是由自动调节转录-翻译反馈环路（TTFL）组成的分子钟产生的24小时节律，支配着行为和生理的时间组织。昼夜节律紊乱会引发或参与不同的病理特征，导致包括癌症在内的一系列病症。时钟对表型可塑性的控制参与了肿瘤发生过程中的异常去分化至祖细胞样细胞状态、癌症干细胞（CSCs）的生成以及上皮细胞向间质转化（EMT）事件。昼夜节律可能是细胞衰老调控机制和衰老相关分泌表型（SASP）功能决定因素的候选者。时钟与表观遗传学之间的相互控制揭示了昼夜节律的转录后调控，为新型抗癌策略开辟了途径。此外，扰乱昼夜节律会影响微生物群落，而微生物群落可能与导致癌症发展的稳态改变有关。在此，我们总结了支持昼夜节律紊乱与癌症新特征之间关系的最新进展，从而为癌症管理的潜在有效治疗方法提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer letters 医学-肿瘤学

CiteScore

17.70

自引率

2.10%

发文量

427

审稿时长

15 days

期刊介绍： Cancer Letters is a reputable international journal that serves as a platform for significant and original contributions in cancer research. The journal welcomes both full-length articles and Mini Reviews in the wide-ranging field of basic and translational oncology. Furthermore, it frequently presents Special Issues that shed light on current and topical areas in cancer research. Cancer Letters is highly interested in various fundamental aspects that can cater to a diverse readership. These areas include the molecular genetics and cell biology of cancer, radiation biology, molecular pathology, hormones and cancer, viral oncology, metastasis, and chemoprevention. The journal actively focuses on experimental therapeutics, particularly the advancement of targeted therapies for personalized cancer medicine, such as metronomic chemotherapy. By publishing groundbreaking research and promoting advancements in cancer treatments, Cancer Letters aims to actively contribute to the fight against cancer and the improvement of patient outcomes.