Pancreatic Cancer-Associated Fibroblasts: Where Do We Go from Here?

IF 12.5 1区医学 Q1 ONCOLOGY

Cancer research Pub Date : 2024-11-04 DOI:10.1158/0008-5472.CAN-24-2860

Eileen S Carpenter, Debora Barbosa Vendramini-Costa, Marie C Hasselluhn, Anirban Maitra, Kenneth P Olive, Edna Cukierman, Marina Pasca di Magliano, Mara H Sherman

引用次数: 0

Abstract

Pancreatic ductal adenocarcinoma is a deadly disease and is projected to become the second leading cause of cancer-related death by 2030. A major hallmark is the exuberant host response comprising the tumor microenvironment, of which, cancer-associated fibroblasts (CAF) are a prevalent component. Despite the gains in understanding of their heterogeneity and functionality from CAF studies in recent years, there are many unanswered questions surrounding this diverse population of cells. Here, we summarize the views of several experts in the field, focusing on the current understanding of CAFs and challenges to address.

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胰腺癌相关成纤维细胞：何去何从？

胰腺导管腺癌是一种致命疾病，预计到 2030 年将成为癌症相关死亡的第二大原因。其主要特征是由肿瘤微环境构成的旺盛的宿主反应，而癌症相关成纤维细胞（CAFs）是肿瘤微环境的主要组成部分。尽管近年来对 CAF 的研究加深了对其异质性和功能性的了解，但围绕这一多样化的细胞群体仍有许多未解之谜。在此，我们总结了该领域几位专家的观点，重点介绍了目前对 CAFs 的理解和需要应对的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer research 医学-肿瘤学

CiteScore

16.10

自引率

0.90%

发文量

7677

审稿时长

2.5 months

期刊介绍： Cancer Research, published by the American Association for Cancer Research (AACR), is a journal that focuses on impactful original studies, reviews, and opinion pieces relevant to the broad cancer research community. Manuscripts that present conceptual or technological advances leading to insights into cancer biology are particularly sought after. The journal also places emphasis on convergence science, which involves bridging multiple distinct areas of cancer research. With primary subsections including Cancer Biology, Cancer Immunology, Cancer Metabolism and Molecular Mechanisms, Translational Cancer Biology, Cancer Landscapes, and Convergence Science, Cancer Research has a comprehensive scope. It is published twice a month and has one volume per year, with a print ISSN of 0008-5472 and an online ISSN of 1538-7445. Cancer Research is abstracted and/or indexed in various databases and platforms, including BIOSIS Previews (R) Database, MEDLINE, Current Contents/Life Sciences, Current Contents/Clinical Medicine, Science Citation Index, Scopus, and Web of Science.