{"title":"Peak enhancement in contrast-enhanced ultrasound for assessing endoscopic disease activity in patients with Crohn's disease: a meta-analysis.","authors":"Lei Yuan, Ruifang Hao, Leilei Zou, Deyin Zhai, Junlian Wang, Ruining Jiao","doi":"10.1177/02841851241275982","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Contrast-enhanced ultrasound (CEUS) has been proposed as a valuable tool for detecting disease activity in patients with Crohn's disease (CD). However, previous studies have utilized different parameters, leading to variation in clinical assessment of this technique.</p><p><strong>Purpose: </strong>To assess the effectiveness of peak enhancement (PE) in CEUS for evaluating endoscopic disease activity in patients with CD.</p><p><strong>Material and methods: </strong>Articles were obtained by searching PubMed, Embase, Web of Science, Wanfang, and CNKI databases. Only studies that investigated the effectiveness of PE in CEUS to discriminate endoscopic disease activity in patients with CD were considered. Pooled sensitivity and specificity were then calculated using a random effects model.</p><p><strong>Results: </strong>Overall, seven studies were included. The endoscopic disease activity of CD was determined based on the simple endoscopic score for Crohn's disease and Crohn's Disease Endoscopic Index of Severity scores. Pooled results showed that a high PE was associated with increased detection efficacy for endoscopic disease activity in CD. Pooled sensitivity, specificity, and positive and negative likelihood ratios were 0.88 (95% confidence interval [CI] = 0.71-0.96), 0.88 (95% CI = 0.81-0.93), 7.60 (95% CI = 4.61-12.53), and 0.14 (95% CI = 0.05-0.35), respectively. The pooled receiver operating characteristic was 0.90 (95% CI = 0.87-0.92), suggesting a good discriminating efficacy of PE in CEUS for endoscopic disease activity of patients with CD.</p><p><strong>Conclusions: </strong>A high PE in CEUS displayed substantial distinguishing accuracy for assessing endoscopic disease activity of patients with CD.</p>","PeriodicalId":7143,"journal":{"name":"Acta radiologica","volume":" ","pages":"1170-1177"},"PeriodicalIF":1.1000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta radiologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/02841851241275982","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Contrast-enhanced ultrasound (CEUS) has been proposed as a valuable tool for detecting disease activity in patients with Crohn's disease (CD). However, previous studies have utilized different parameters, leading to variation in clinical assessment of this technique.
Purpose: To assess the effectiveness of peak enhancement (PE) in CEUS for evaluating endoscopic disease activity in patients with CD.
Material and methods: Articles were obtained by searching PubMed, Embase, Web of Science, Wanfang, and CNKI databases. Only studies that investigated the effectiveness of PE in CEUS to discriminate endoscopic disease activity in patients with CD were considered. Pooled sensitivity and specificity were then calculated using a random effects model.
Results: Overall, seven studies were included. The endoscopic disease activity of CD was determined based on the simple endoscopic score for Crohn's disease and Crohn's Disease Endoscopic Index of Severity scores. Pooled results showed that a high PE was associated with increased detection efficacy for endoscopic disease activity in CD. Pooled sensitivity, specificity, and positive and negative likelihood ratios were 0.88 (95% confidence interval [CI] = 0.71-0.96), 0.88 (95% CI = 0.81-0.93), 7.60 (95% CI = 4.61-12.53), and 0.14 (95% CI = 0.05-0.35), respectively. The pooled receiver operating characteristic was 0.90 (95% CI = 0.87-0.92), suggesting a good discriminating efficacy of PE in CEUS for endoscopic disease activity of patients with CD.
Conclusions: A high PE in CEUS displayed substantial distinguishing accuracy for assessing endoscopic disease activity of patients with CD.
背景：对比增强超声（CEUS）被认为是检测克罗恩病患者疾病活动性的重要工具。目的：评估CEUS中峰值增强（PE）对评估CD患者内镜下疾病活动性的有效性：通过检索PubMed、Embase、Web of Science、Wanfang和CNKI数据库获得相关文章。只有研究了CEUS中的PE对CD患者内镜下疾病活动性的鉴别效果的研究才被考虑在内。然后使用随机效应模型计算汇总的敏感性和特异性：结果：共纳入七项研究。根据克罗恩病内镜下简单评分和克罗恩病内镜下严重程度指数评分确定了 CD 的内镜下疾病活动度。汇总结果显示，高PE与CD内镜下疾病活动性的检测效力增加有关。汇总的敏感性、特异性以及阳性和阴性似然比分别为 0.88（95% 置信区间 [CI] = 0.71-0.96）、0.88（95% CI = 0.81-0.93）、7.60（95% CI = 4.61-12.53）和 0.14（95% CI = 0.05-0.35）。集合接收者操作特征为0.90（95% CI = 0.87-0.92），表明CEUS中的PE对CD患者内镜下疾病活动具有良好的鉴别效果：结论：CEUS中的高PE在评估CD患者内镜下疾病活动性方面具有很高的鉴别准确性。
期刊介绍：
Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.
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