Based on the clinical features of cytologically intrinsic chronic rhinosinusitis with nasal polyps.

IF 1.2 4区 医学 Q3 OTORHINOLARYNGOLOGY
Acta Oto-Laryngologica Pub Date : 2024-09-01 Epub Date: 2024-09-21 DOI:10.1080/00016489.2024.2396487
Ruru Tian, Jianhua Jiang, Xiangyan Wu, Jie Ling Zhao, Xin Ru Zhou, Jinv Ding
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引用次数: 0

Abstract

Background: The clinical phenotypes of CRS, such as the presence or absence of polyps, cannot well reflect the pathophysiological mechanisms and characteristics of patients. Only by distinguishing the different internal types of CRS can we individualize patients more accurately.

Objective: To investigate the clinical characteristics of chronic rhinosinusitis with different cell types (CRSwNP), and to provide a reference for the diagnosis and treatment of CRSwNP.

Materials and methods: The cytological endotypes of CRSwNP were divided into five groups by cluster analysis.

Results: There was a significant difference in the proportion of CRSwNP with different endotypes. There were significant differences in peripheral blood eosinophils, cerebrovascular disease, and unilateral and bilateral nasal polyps among CRSWNP patients with different cytological types.

Conclusions: Mixed CRSwNP and eosinophilic CRSwNP are the most common, while neutrophilic CRSWNP is the least common. Eosinophilic CRSwNP is more common in bilateral nasal polyps, with a high recurrence rate and a high probability of olfactory dysfunction. Neutrophilic CRSwNP is more common in elderly patients with cardiovascular and cerebrovascular diseases. Compared with total serum IgE, the percentage of eosinophils in peripheral blood is more helpful for the diagnosis of eosinophilic CRSwNP.

根据细胞学内在性慢性鼻窦炎伴鼻息肉的临床特征。
背景:CRS的临床表型,如有无息肉,不能很好地反映患者的病理生理机制和特征。只有区分 CRS 的不同内部类型,才能更准确地对患者进行个体化治疗:研究不同细胞类型慢性鼻窦炎(CRSwNP)的临床特征,为CRSwNP的诊断和治疗提供参考:通过聚类分析将CRSwNP的细胞学内型分为五组:结果:不同内型的CRSwNP比例存在明显差异。不同细胞学类型的 CRSwNP 患者在外周血嗜酸性粒细胞、脑血管疾病、单侧和双侧鼻息肉方面存在明显差异:结论:混合型 CRSwNP 和嗜酸性 CRSwNP 最常见,而嗜中性 CRSWNP 最不常见。嗜酸性 CRSwNP 更常见于双侧鼻息肉,复发率高,出现嗅觉功能障碍的概率也很高。嗜中性粒细胞 CRSwNP 更常见于患有心脑血管疾病的老年患者。与血清总 IgE 相比,外周血中嗜酸性粒细胞的百分比更有助于诊断嗜酸性粒细胞性 CRSwNP。
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来源期刊
Acta Oto-Laryngologica
Acta Oto-Laryngologica 医学-耳鼻喉科学
CiteScore
2.50
自引率
0.00%
发文量
99
审稿时长
3-6 weeks
期刊介绍: Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.
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