Roles of epidural block in combination with general anesthesia in stress response and immune function of patients after surgery for cervical cancer.

IF 2.9 4区生物学 Q3 CELL BIOLOGY

Journal of Molecular Histology Pub Date : 2024-09-23 DOI:10.1007/s10735-024-10266-6

Bingjie Zhao, Yang Liu, Huan Lu

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引用次数: 0

Abstract

We aimed to explore the roles of epidural block in combination with general anesthesia in the stress response and immune function of patients after surgery for cervical cancer. A total of 108 patients undergoing radical surgery of cervical cancer were randomly assigned into a general anesthesia combined with epidural block (observation) group and a general anesthesia (control) group. Peripheral blood was collected before anesthesia (t0), during anesthesia maintenance, as well as 10 min, 1 d, 2 d and 7 d after surgery. The levels of cytokines interferon-γ (IFN-γ), interleukin-4 (IL-4) and transforming growth factor-β1 (TGF-β1) were detected by ELISA, and IFN-γ/IL-4 ratio was calculated. Compared with the control group, the observation group had significantly lower levels of GH, PRL and Cor, proportions of Th2 and Treg cells, and levels of IL-4 and TGF-β1 during anesthesia maintenance and at each time point after surgery (P < 0.05), but higher proportion of Th1 cells, Th1/Th2 cell ratio, IFN-γ level and IFN-γ/IL-4 ratio (P < 0.05). General anesthesia in combination with epidural block can work better in mitigating the stress response and protecting the immune function of patients after cervical cancer surgery.

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硬膜外阻滞结合全身麻醉对宫颈癌术后患者应激反应和免疫功能的影响。

我们旨在探讨硬膜外阻滞结合全身麻醉对宫颈癌术后患者应激反应和免疫功能的影响。我们将 108 名接受宫颈癌根治术的患者随机分为全身麻醉联合硬膜外阻滞组（观察组）和全身麻醉组（对照组）。分别在麻醉前（t0）、麻醉维持期间、术后 10 分钟、1 天、2 天和 7 天采集外周血。用 ELISA 方法检测细胞因子干扰素-γ（IFN-γ）、白细胞介素-4（IL-4）和转化生长因子-β1（TGF-β1）的水平，并计算 IFN-γ/IL-4 的比值。与对照组相比，观察组在麻醉维持期间和术后各时间点的 GH、PRL 和 Cor 水平、Th2 和 Treg 细胞比例、IL-4 和 TGF-β1 水平均显著降低（P＜0.05）。

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来源期刊

Journal of Molecular Histology 生物-细胞生物学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Molecular Histology publishes results of original research on the localization and expression of molecules in animal cells, tissues and organs. Coverage includes studies describing novel cellular or ultrastructural distributions of molecules which provide insight into biochemical or physiological function, development, histologic structure and disease processes. Major research themes of particular interest include: - Cell-Cell and Cell-Matrix Interactions; - Connective Tissues; - Development and Disease; - Neuroscience. Please note that the Journal of Molecular Histology does not consider manuscripts dealing with the application of immunological or other probes on non-standard laboratory animal models unless the results are clearly of significant and general biological importance. The Journal of Molecular Histology publishes full-length original research papers, review articles, short communications and letters to the editors. All manuscripts are typically reviewed by two independent referees. The Journal of Molecular Histology is a continuation of The Histochemical Journal.