Advanced Biomaterials Derived from Functional Polyphosphoesters: Synthesis, Properties, and Biomedical Applications

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-09-23 DOI:10.1021/acsami.4c11899

Jintao Li, Ying Hao, Hairong Wang, Mingzu Zhang, Jinlin He, Peihong Ni

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Abstract

Polyphosphoesters (PPEs) represent an innovative class of biodegradable polymers, with the phosphate ester serving as the core repeating unit of their polymeric backbone. Recently, biomaterials derived from functionalized PPEs have garnered significant interest in biomedical applications because of their commendable biocompatibility, biodegradability, and the capacity for functional modification. This review commences with a brief overview of synthesis methodologies and the distinctive properties of PPEs, including thermoresponsiveness, degradability, stealth effect, and biocompatibility. Subsequently, the review delves into the latest applications of PPEs-based nanocarriers for drug or gene delivery and PPEs-based polymeric prodrugs and scaffolds in the biomedical field, presenting several illustrative examples for each application. By encapsulating the advancements of recent years, this review aims to offer an enhanced understanding and serve as a reference for the synthesis and biomedical applications of functional PPEs.

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功能性聚磷酯衍生的先进生物材料：合成、特性和生物医学应用

聚磷酸酯（PPE）是一类创新的可生物降解聚合物，磷酸酯是其聚合物骨架的核心重复单元。最近，由功能化 PPE 衍生的生物材料在生物医学应用领域引起了极大的兴趣，因为它们具有良好的生物相容性、生物降解性和功能修饰能力。本综述首先简要介绍了 PPE 的合成方法和独特性质，包括热致性、可降解性、隐形效应和生物相容性。随后，综述深入探讨了基于 PPE 的纳米载体在生物医学领域的最新应用，包括用于药物或基因递送的纳米载体，以及基于 PPE 的聚合物原药和支架，并针对每种应用介绍了几个示例。通过总结近年来的研究进展，本综述旨在加深人们对功能性 PPE 的理解，并为功能性 PPE 的合成和生物医学应用提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.

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