A new perspective in intestinal microecology: lifting the veil of exercise regulation of cardiometabolic diseases.

IF 12.2 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gut Microbes Pub Date : 2024-09-21 DOI:10.1080/19490976.2024.2404141

Can Gao,Jinwen Wei,Changxu Lu,Lijie Wang,Dan Dong,Mingli Sun

{"title":"A new perspective in intestinal microecology: lifting the veil of exercise regulation of cardiometabolic diseases.","authors":"Can Gao,Jinwen Wei,Changxu Lu,Lijie Wang,Dan Dong,Mingli Sun","doi":"10.1080/19490976.2024.2404141","DOIUrl":null,"url":null,"abstract":"Cardiometabolic diseases (CMDs), encompassing cardiovascular and metabolic dysfunctions, characterized by insulin resistance, dyslipidemia, hepatic steatosis, and inflammation, have been identified with boosting morbidity and mortality due to the dearth of efficacious therapeutic interventions. In recent years, studies have shown that variations in gut microbiota and its own metabolites can influence the occurrence of CMDs. Intriguingly, the composition and function of the gut microbiota are susceptible to exercise patterns, thus affecting inflammatory, immune, and metabolic responses within the host. In this review, we introduce the key mechanisms of intestinal microecology involved in the onset and development of CMDs, discuss the relationship between exercise and intestinal microecology, and then analyze the role of intestinal microecology in the beneficial effects of exercise on CMDs, aiming at elucidating the gut-heart axis mechanisms of exercise mediated protective effect on CMDs, building avenues for the application of exercise in the management of CMDs.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"20 1","pages":"2404141"},"PeriodicalIF":12.2000,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gut Microbes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/19490976.2024.2404141","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Cardiometabolic diseases (CMDs), encompassing cardiovascular and metabolic dysfunctions, characterized by insulin resistance, dyslipidemia, hepatic steatosis, and inflammation, have been identified with boosting morbidity and mortality due to the dearth of efficacious therapeutic interventions. In recent years, studies have shown that variations in gut microbiota and its own metabolites can influence the occurrence of CMDs. Intriguingly, the composition and function of the gut microbiota are susceptible to exercise patterns, thus affecting inflammatory, immune, and metabolic responses within the host. In this review, we introduce the key mechanisms of intestinal microecology involved in the onset and development of CMDs, discuss the relationship between exercise and intestinal microecology, and then analyze the role of intestinal microecology in the beneficial effects of exercise on CMDs, aiming at elucidating the gut-heart axis mechanisms of exercise mediated protective effect on CMDs, building avenues for the application of exercise in the management of CMDs.

查看原文本刊更多论文

肠道微生态学的新视角：揭开运动调节心脏代谢疾病的面纱。

心血管代谢疾病（CMDs）包括心血管和代谢功能障碍，以胰岛素抵抗、血脂异常、肝脂肪变性和炎症为特征，由于缺乏有效的治疗干预措施，其发病率和死亡率不断上升。近年来的研究表明，肠道微生物群及其自身代谢产物的变化可影响 CMD 的发生。有趣的是，肠道微生物群的组成和功能易受运动模式的影响，从而影响宿主体内的炎症、免疫和代谢反应。在这篇综述中，我们介绍了肠道微生态参与CMD发病和发展的关键机制，讨论了运动与肠道微生态之间的关系，然后分析了肠道微生态在运动对CMD的有益影响中的作用，旨在阐明运动介导的肠道-心脏轴对CMD的保护作用机制，为运动在CMD管理中的应用开辟途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Gut Microbes Medicine-Microbiology (medical)

CiteScore

18.20

自引率

3.30%

发文量

196

审稿时长

10 weeks

期刊介绍： The intestinal microbiota plays a crucial role in human physiology, influencing various aspects of health and disease such as nutrition, obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and more. Gut Microbes serves as a platform for showcasing and discussing state-of-the-art research related to the microorganisms present in the intestine. The journal emphasizes mechanistic and cause-and-effect studies. Additionally, it has a counterpart, Gut Microbes Reports, which places a greater focus on emerging topics and comparative and incremental studies.