Lymphopenia in sepsis: a narrative review

IF 8.8 1区医学 Q1 CRITICAL CARE MEDICINE

Critical Care Pub Date : 2024-09-20 DOI:10.1186/s13054-024-05099-4

Zhibin Wang, Wenzhao Zhang, Linlin Chen, Xin Lu, Ye Tu

引用次数: 0

Abstract

This narrative review provides an overview of the evolving significance of lymphopenia in sepsis, emphasizing its critical function in this complex and heterogeneous disease. We describe the causal relationship of lymphopenia with clinical outcomes, sustained immunosuppression, and its correlation with sepsis prediction markers and therapeutic targets. The primary mechanisms of septic lymphopenia are highlighted. In addition, the paper summarizes various attempts to treat lymphopenia and highlights the practical significance of promoting lymphocyte proliferation as the next research direction.

查看原文本刊更多论文

败血症中的淋巴细胞减少症：叙述性综述

这篇叙述性综述概述了淋巴细胞减少症在脓毒症中不断演变的意义，强调了淋巴细胞减少症在这种复杂而多变的疾病中的关键作用。我们描述了淋巴细胞减少症与临床结果、持续免疫抑制的因果关系，以及它与脓毒症预测指标和治疗目标的相关性。文章还强调了脓毒症淋巴细胞减少症的主要机制。此外，本文还总结了治疗淋巴细胞减少症的各种尝试，并强调了促进淋巴细胞增殖作为下一个研究方向的现实意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Critical Care 医学-危重病医学

CiteScore

20.60

自引率

3.30%

发文量

348

审稿时长

1.5 months

期刊介绍： Critical Care is an esteemed international medical journal that undergoes a rigorous peer-review process to maintain its high quality standards. Its primary objective is to enhance the healthcare services offered to critically ill patients. To achieve this, the journal focuses on gathering, exchanging, disseminating, and endorsing evidence-based information that is highly relevant to intensivists. By doing so, Critical Care seeks to provide a thorough and inclusive examination of the intensive care field.