A Brief Review of Vehicles for Topical Therapies.

IF 2.8 4区医学 Q2 DERMATOLOGY

Skin Pharmacology and Physiology Pub Date : 2024-09-12 DOI:10.1159/000541418

Kripa Ahuja,Miranda An,Peter Lio

引用次数: 0

Abstract

Background Topical therapy has been a fundamental part of dermatology, evolving from early ointments to advanced transdermal treatments. These formulations allow for effective management of skin conditions by maximizing local drug delivery and minimizing systemic effects. Modern topical therapies continue to benefit from innovations that improve both efficacy and patient outcomes. Summary Topical formulations consist of a vehicle and active ingredients, with the vehicle enhancing drug absorption and patient experience. Historically categorized by physical properties, vehicles are vital in drug delivery. Recent innovations, such as nanoemulsions and derma-membrane structures, offer improved skin penetration and therapeutic results, representing significant advancements in topical treatment options. Key Messages Topical therapies provide targeted, effective treatment in dermatology with minimal systemic side effects. Vehicle choice is essential to therapy success, and innovations such as nanoemulsions are improving drug delivery and patient care. Ongoing research into novel delivery systems continues to enhance the future of dermatological treatments.

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局部疗法载体简评

背景外用疗法一直是皮肤病学的基本组成部分，从早期的软膏发展到先进的透皮疗法。这些制剂通过最大限度地增加局部给药量和减少全身影响来有效治疗皮肤病。现代外用疗法不断从创新中获益，从而提高了疗效，改善了患者的预后。摘要外用制剂由载体和活性成分组成，载体可促进药物吸收，改善患者体验。载体历来按物理特性分类，在给药过程中至关重要。纳米乳剂和皮肤膜结构等最新创新技术可提高皮肤渗透性和治疗效果，是外用治疗方法的重大进步。关键信息外用疗法为皮肤病提供了有针对性的有效治疗，并将全身副作用降至最低。载体的选择对治疗的成功至关重要，而纳米乳剂等创新技术正在改善药物输送和患者护理。对新型给药系统的持续研究将继续促进皮肤病治疗的未来发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Skin Pharmacology and Physiology 医学-皮肤病学

CiteScore

5.20

自引率

7.40%

发文量

审稿时长

>12 weeks

期刊介绍： In the past decade research into skin pharmacology has rapidly developed with new and promising drugs and therapeutic concepts being introduced regularly. Recently, the use of nanoparticles for drug delivery in dermatology and cosmetology has become a topic of intensive research, yielding remarkable and in part surprising results. Another topic of current research is the use of tissue tolerable plasma in wound treatment. Stimulating not only wound healing processes but also the penetration of topically applied substances into the skin, this novel technique is expected to deliver very interesting results.