Investigating the metabolic alterations of metastatic and local prostate cancer patients via PET/CT assisted untargeted metabolomics approach

IF 1.5 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2024-09-19 DOI:10.1007/s10967-024-09760-8

Adem Maman, Onur Senol

引用次数: 0

Abstract

Prostate cancer is a very common and widespread health problem all over the world. It mostly metastases into bone tissues and pathogenesis become more complicated. In this study, it is aimed to explain etiopathogenesis of local and metastatic prostate cancer via untargeted metabolomics approach. The study was conducted by arranging 36 eligible patients. Their metastasis level were monitored via ⁶⁸Ga-PSMA PET/CT. The large load of tumor cells mostly impacted phenylalanine, tyrosine, thiamin biosynthesis, aminoacyl t-RNA production, and energy metabolism. This PET/CT assisted metabolomics approach may lead to a new perspective on the pathogenesis of high tumour burden on metastasis.

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通过 PET/CT 辅助非靶向代谢组学方法研究转移性和局部前列腺癌患者的代谢变化

前列腺癌是全世界非常常见和普遍的健康问题。前列腺癌大多转移到骨组织，发病机制也变得更加复杂。本研究旨在通过非靶向代谢组学方法解释局部和转移性前列腺癌的发病机制。研究安排了 36 名符合条件的患者。通过68Ga-PSMA PET/CT监测他们的转移水平。大量肿瘤细胞主要影响苯丙氨酸、酪氨酸、硫胺的生物合成、氨基酰 t-RNA 的产生以及能量代谢。这种 PET/CT 辅助代谢组学方法可为研究高肿瘤负荷导致转移的发病机制提供新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.