Ivermectin-based products in the context of green pharmaceutical analysis

IF 1.7 4区农林科学 Q3 CHEMISTRY, ANALYTICAL

Journal of AOAC International Pub Date : 2024-09-18 DOI:10.1093/jaoacint/qsae072

Natália Sabina dos Santos Galvão, Ana Carolina Kogawa

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Abstract

Background Ivermectin (IVE), a broad-spectrum antiparasitic, is used in human and animal health. Analytical methods for evaluating IVE in pharmaceutical products are found in the literature and in official compendiums. However, the vast majority of them do not have an eco-friendly approach. Objective and Method The aim of this review is to present an overview of existing analytical methods for evaluating IVE in pharmaceutical matrices in the context of Green Analytical Chemistry (GAC) and show possibilities for increasing their greenness. Results GAC is a current alternative to promote sustainable development in laboratories and chemical-pharmaceutical industries, therefore, through its principles, such as reducing the use of aggressive solvents, it is possible to make processes more ecological. However, the vast majority of analytical methods available in the literature and official compendiums do not present an eco-friendly approach. 70% of the methods are by HPLC. Among the various pharmaceutical matrices, the most evaluated are tablets (37%). Of all the solvents used in HPLC, UPLC, HPLC-MS/MS, UV and TLC methods, the combination of methanol and acetonitrile is the most chosen, accounting for more than 50% of occurrences. Conclusions Analytical methods for evaluating IVE-based products can be leveraged within the scope of GAC, bringing sustainable work opportunities to analytical development laboratories around the world. Highlights This review shows an overview of the analytical methods present in the literature and official compendiums to evaluate pharmaceutical IVE matrices, in the context of green analytical chemistry.

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绿色药物分析中的伊维菌素类产品

背景伊维菌素（IVE）是一种广谱抗寄生虫药物，用于人类和动物健康。评估药品中伊维菌素含量的分析方法见诸于文献和官方药典。然而，其中绝大多数都没有采用生态友好型方法。目的和方法本综述旨在概述在绿色分析化学（GAC）背景下评估药物基质中 IVE 的现有分析方法，并说明提高其绿色性的可能性。结果绿色分析化学（GAC）是目前促进实验室和化学制药行业可持续发展的一种替代方法，因此，通过其原则（如减少侵蚀性溶剂的使用），有可能使流程更加生态化。然而，文献和官方简编中的绝大多数分析方法都没有采用生态友好型方法。其中 70% 的方法采用的是高效液相色谱法。在各种药物基质中，评估最多的是片剂（37%）。在 HPLC、UPLC、HPLC-MS/MS、UV 和 TLC 方法中使用的所有溶剂中，甲醇和乙腈的组合是最常用的，占 50%以上。结论评估基于 IVE 的产品的分析方法可在 GAC 范围内加以利用，为世界各地的分析开发实验室带来可持续的工作机会。亮点本综述概述了在绿色分析化学背景下，文献和官方汇编中用于评估药物 IVE 基质的分析方法。

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来源期刊

Journal of AOAC International 医学-分析化学

CiteScore

3.10

自引率

12.50%

发文量

144

审稿时长

2.7 months

期刊介绍： The Journal of AOAC INTERNATIONAL publishes the latest in basic and applied research in analytical sciences related to foods, drugs, agriculture, the environment, and more. The Journal is the method researchers'' forum for exchanging information and keeping informed of new technology and techniques pertinent to regulatory agencies and regulated industries.