The first non-symmetrically substituted conjugates of bispidine with monoterpenoids and amino acids. Synthesis and application for catalysis of addition of diethylzinc to aldehydes
IF 1.7
4区 化学
Q3 CHEMISTRY, MULTIDISCIPLINARY
引用次数: 0
Abstract
A series of bispidine conjugates bearing monoterpene moieties and either l-proline or l-phenylalanine residues was synthesized. The synthesized bispidines can catalyze asymmetric ethylation of benzaldehydes with diethylzinc. The highest enantioselectivity of the addition reaction (ee 24%) was achieved for bispidine with (–)-α-pinene and Boc-l-proline moieties.
双脒与单萜和氨基酸的第一种非对称取代共轭物。二乙基锌的合成及其在醛加成催化中的应用
我们合成了一系列含有单萜分子和 l-脯氨酸或 l-苯丙氨酸残基的双脒共轭物。合成的双脒能催化苯甲醛与二乙基锌的不对称乙基化反应。具有 (-)-α蒎烯和叔丁氧羰基-l-脯氨酸的双脒在加成反应中实现了最高的对映选择性（ee 24%）。
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来源期刊
Russian Chemical Bulletin
化学-化学综合
CiteScore
2.70
自引率
47.10%
发文量
257
审稿时长
3-8 weeks
期刊介绍：
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.
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