A new test for evaluation of marginal cognitive function deficits in idiopathic normal pressure hydrocephalus through expressing texture recognition by sound symbolic words

IF 4.1 2区医学 Q2 GERIATRICS & GERONTOLOGY

Frontiers in Aging Neuroscience Pub Date : 2024-09-18 DOI:10.3389/fnagi.2024.1456242

Chihiro Kamohara, Madoka Nakajima, Yuji Nozaki, Taiki Ieda, Kaito Kawamura, Kou Horikoshi, Ryo Miyahara, Chihiro Akiba, Ikuko Ogino, Kostadin L. Karagiozov, Masakazu Miyajima, Akihide Kondo, Maki Sakamoto

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引用次数: 0

Abstract

IntroductionThe number of dementia patients is increasing with population aging. Preclinical detection of dementia in patients is essential for access to adequate treatment. In previous studies, dementia patients showed texture recognition difficulties. Onomatopoeia or sound symbolic words (SSW) are intuitively associated with texture impressions and are less likely to be affected by aphasia and description of material perception can be easily obtained. In this study, we aimed to create a test of texture recognition ability expressed by SSW to detect the presence of mild cognitive disorders.MethodsThe sound symbolic words texture recognition test (SSWTRT) is constructed from 12 close-up photos of various materials and participants were to choose the best SSW out of 8 choices to describe surface texture in the images in Japanese. All 102 participants seen in Juntendo University Hospital from January to August 2023 had a diagnosis of possible iNPH (age mean 77.9, SD 6.7). The answers were scored on a comprehensive scale of 0 to 1. Neuropsychological assessments included MMSE, FAB, and the Rey Auditory Verbal Learning Test (RAVLT), Pegboard Test, and Stroop Test from the EU-iNPH Grading Scale (GS). In study 1 the correlation between SSWTRT and the neuropsychological tests were analyzed. In study 2, participants were divided into two groups: the Normal Cognition group (Group A, n = 37) with MMSE scores of 28 points or above, and the Mild Cognitive Impairment group (Group B, n = 50) with scores ranging from 22 to 27 points, and its predictability were analyzed.ResultsIn study 1, the total SSWTRT score had a moderate correlation with the neuropsychological test results. In study 2, there were significant differences in the SSWTRT scores between groups A and B. ROC analysis results showed that the SSWTR test was able to predict the difference between the normal and mildly impaired cognition groups.ConclusionThe developed SSWTRT reflects the assessment results of neuropsychological tests in cognitive deterioration and was able to detect early cognitive deficits. This test not only relates to visual perception but is likely to have an association with verbal fluency and memory ability, which are frontal lobe functions.

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通过声音符号词表达纹理识别，评估特发性正常压力脑积水边缘认知功能障碍的新测试

导言：随着人口老龄化，痴呆症患者人数不断增加。对痴呆症患者进行临床前检测对于获得适当的治疗至关重要。在以往的研究中，痴呆症患者表现出纹理识别困难。拟声词或声音符号词（SSW）与质地印象有直观联系，受失语症影响的可能性较小，而且可以很容易地获得对物质感知的描述。方法声音符号词质感识别测试（SSWTRT）由 12 张各种材料的特写照片构成，参与者需要从 8 个选项中选出最佳的 SSW，用日语描述图片中的表面质感。2023 年 1 月至 8 月期间在顺天堂大学医院就诊的 102 名参与者均被诊断为可能患有 iNPH（平均年龄 77.9 岁，标准差 6.7 岁）。答案采用 0 至 1 的综合评分法。神经心理学评估包括MMSE、FAB、雷伊听觉言语学习测试（RAVLT）、Pegboard测试和欧盟iNPH分级量表（GS）中的Stroop测试。研究 1 分析了 SSWTRT 与神经心理测试之间的相关性。在研究 2 中，参与者被分为两组：MMSE 得分在 28 分或以上的认知正常组（A 组，n = 37）和得分在 22 分至 27 分之间的轻度认知障碍组（B 组，n = 50），并对其预测性进行了分析。ROC分析结果表明，SSWTRT能预测正常组和轻度认知障碍组之间的差异。结论开发的SSWTRT反映了认知退化中神经心理学测试的评估结果，并能发现早期认知障碍。该测试不仅与视觉感知有关，还可能与属于额叶功能的语言流畅性和记忆能力有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.