Assessment of central vein sign and paramagnetic rim lesions in pediatric multiple sclerosis

IF 4.4 2区医学 Q1 CLINICAL NEUROLOGY

Annals of Clinical and Translational Neurology Pub Date : 2024-09-18 DOI:10.1002/acn3.52208

Monica Margoni, Paolo Preziosa, Elisabetta Pagani, Loredana Storelli, Mor Gueye, Lucia Moiola, Massimo Filippi, Maria A. Rocca

引用次数: 0

Abstract

The evaluation of white matter lesions (WMLs) showing the central vein sign (CVS) and paramagnetic rim lesions (PRLs) has been suggested to enhance the diagnostic work-up of adult multiple sclerosis (MS). We aimed to evaluate the fulfillment of different CVS criteria and the added value of PRLs in 22 pediatric MS patients. Eleven patients (50%) fulfilled the 40%-rule threshold. Nineteen (86%) patients had ≥3 CVS+ WMLs or ≥1 PRL, whereas 17 (77%) had ≥6 CVS+ WMLs or ≥1 PRL. A simplified CVS-based approach, with the combined evaluation of ≥1 PRL in patients with ≥6 CVS+ WMLs, may improve MS diagnosis in pediatric patients.

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评估小儿多发性硬化症的中央静脉征和顺磁性边缘病变

有人建议对显示中央静脉征（CVS）的白质病变（WMLs）和顺磁性边缘病变（PRLs）进行评估，以加强成人多发性硬化症（MS）的诊断工作。我们的目的是评估 22 名儿童多发性硬化症患者是否符合不同的 CVS 标准以及 PRLs 的附加价值。11名患者（50%）符合40%规则阈值。19名患者（86%）有≥3个CVS+ WML或≥1个PRL，而17名患者（77%）有≥6个CVS+ WML或≥1个PRL。在≥6个CVS+ WMLs的患者中合并评估≥1个PRL，这种基于CVS的简化方法可能会改善儿童患者的MS诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.