Association between Cognitive Reserve Indicator and Chronic Disease-Free Survival: A Large Community-Based Longitudinal Study

IF 4.3 Q2 BUSINESS
P. Li, W. Yang, J. Wang, Hong Zhu, A. Dove, Weili Xu
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引用次数: 0

Abstract

Background

Cognitive reserve (CR) has been linked to dementia and might be a predictor of aged-related outcomes. However, the association between CR and risk of other chronic diseases and mortality remains unclear.

Objectives

We aimed to investigate the association of CR with survival free from major chronic diseases.

Design, Setting and Participants

This community-based longitudinal study used data from the UK Biobank. A total of 412,509 participants (mean age 55.71±8.10) free of major chronic disease (including dementia, diabetes, cardiovascular diseases, chronic obstructive pulmonary disease, and cancer) completed the baseline examination between 2006 to 2010 and were followed for changes in health status.

Measurements

Latent class analysis was used to generate an indicator of CR (categorized as low, moderate, or high) based on education, occupation, television viewing time, confiding, social connection, and leisure activities. Major chronic diseases and survival status were ascertained through self-reported history and/or linkages to medical and death records. Chronic disease-free survival was defined as survival without any of the aforementioned chronic diseases. Effect modifications and interactions between the CR indicator and sex, age, and lifestyle factors (including smoking status, alcohol consumption, physical activity, and body mass index) were explored.

Results

Over a median follow-up of 12.49 (interquartile range 11.42–13.41, range 0.01–15.87) years, 112,190 (27.2%) participants died or developed at least one chronic disease. High CR indicator was associated with lower risk of chronic disease/death (hazard ratio 0.82, 95% confidence interval: 0.80–0.83) compared to low CR indicator. Chronic disease-free survival was prolonged by 1.33 (1.21–1.44) years among participants with high CR compared to low CR indicator. Furthermore, the association between the CR indicator and chronic disease-free survival was strengthened among individuals aged <60 years and current smokers.

Conclusion

High CR indicator is associated with a lower risk of chronic disease/death and may prolong chronic disease-free survival. Our findings underscore the importance of CR-enhancing lifestyle and experiences in health longevity, especially for younger individuals and current smokers.

Abstract Image

认知储备指标与无慢性病生存率之间的关系:一项大型社区纵向研究
背景认知储备(CR)与痴呆症有关,可能是预测老年相关结果的一个指标。我们旨在研究认知储备与无主要慢性疾病生存率之间的关系。这项基于社区的纵向研究使用了英国生物库的数据。共有 412,509 名参与者(平均年龄为 55.71±8.10 岁)在 2006 年至 2010 年期间完成了基线检查,并对其健康状况的变化进行了跟踪调查,这些参与者均无主要慢性疾病(包括痴呆、糖尿病、心血管疾病、慢性阻塞性肺病和癌症)。主要慢性病和生存状况通过自我报告的病史和/或与医疗和死亡记录的联系来确定。无慢性病存活被定义为无任何上述慢性病的存活。研究还探讨了CR指标与性别、年龄和生活方式因素(包括吸烟状况、饮酒量、体力活动和体重指数)之间的效应修正和交互作用。结果在中位随访12.49年(四分位距为11.42-13.41,范围为0.01-15.87)期间,有112190人(27.2%)死亡或至少罹患一种慢性疾病。与低 CR 指标相比,高 CR 指标与较低的慢性病/死亡风险相关(危险比为 0.82,95% 置信区间为 0.80-0.83)。与低CR指标相比,高CR指标参与者的无慢性病生存期延长了1.33(1.21-1.44)年。结论高 CR 指标与较低的慢性病/死亡风险相关,并可延长无慢性病生存期。我们的研究结果强调了增强 CR 的生活方式和经验对健康长寿的重要性,尤其是对年轻人和当前吸烟者而言。
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来源期刊
The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
CiteScore
9.20
自引率
0.00%
发文量
0
期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
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