Starships: a new frontier for fungal biology

IF 13.6 2区生物学 Q1 GENETICS & HEREDITY

Trends in Genetics Pub Date : 2024-09-18 DOI:10.1016/j.tig.2024.08.006

Andrew Urquhart, Aaron A. Vogan, Emile Gluck-Thaler

引用次数: 0

Abstract

Transposable elements (TEs) are semiautonomous genetic entities that proliferate in genomes. We recently discovered the Starships, a previously hidden superfamily of giant TEs found in a diverse subphylum of filamentous fungi, the Pezizomycotina. Starships are unlike other eukaryotic TEs because they have evolved mechanisms for both mobilizing entire genes, including those encoding conditionally beneficial phenotypes, and for horizontally transferring between individuals. We argue that Starships have unrivaled capacity to engage their fungal hosts as genetic parasites and mutualists, revealing unexplored terrain for investigating the ecoevolutionary dynamics of TE-eukaryote interactions. We build on existing models of fungal genome evolution by conceptualizing Starships as a distinct genomic compartment whose dynamics profoundly shape fungal biology.

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星际飞船：真菌生物学的新领域

可转座元件（Transposable elements，TEs）是在基因组中增殖的半自主遗传实体。我们最近发现了 "星船"（Starships），这是一个以前隐藏的巨型可转座元件超家族，存在于丝状真菌的一个不同亚门--Pezizomycotina中。Starships与其他真核生物TE不同，因为它们进化出了调动整个基因（包括编码条件性有益表型的基因）和在个体间水平转移的机制。我们认为，星船具有无与伦比的能力，能以基因寄生虫和互惠者的身份与真菌宿主接触，为研究 TE 与真核生物相互作用的生态进化动态揭示了尚未开发的领域。我们在现有真菌基因组进化模型的基础上，将星舰概念化为一个独特的基因组区室，其动态变化深刻地影响着真菌生物学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Genetics 生物-遗传学

CiteScore

20.90

自引率

0.90%

发文量

160

审稿时长

6-12 weeks

期刊介绍： Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.