Assessing the risk factors associated with nutritional status in patients with liver cirrhosis: A case-control study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-29 DOI:10.3233/thc-241180

Yanping Ji,Qingbin Ding,Tianyi Bu,Kun Wang,Jing Zhang,Xue Wang

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Abstract

BACKGROUND Cirrhosis is one of the most common clinical diseases in the world. The patient with cirrhosis has many complications, such as spontaneous peritonitis, hepatic encephalopathy. Malnutrition is one of the most common complications in patients with cirrhosis, and it is also a key factor affecting the prognosis of patients. However, the research on cirrhosis malnutrition is relatively scarce. OBJECTIVE This study aimed to explore the new factors of the liver cirrhosis with the nutritional status. METHODS A total of 370 patients with liver cirrhosis were admitted to the Fourth Affiliated Hospital of Harbin Medical University from January 2019 to January 2023 were selected. Patients were assigned to the malnourished group and normal group. The weight, height, mid arm circumference (MAC) and triceps skinfold thickness (TSF) of the two groups were measured. Body mass index (BMI) and mid-arm muscle circumference (MAMC) were calculated. Furthermore, the Health Literacy Management Scale (HeLMS), biochemical indexes, incidence of complications, disease grade were also counted and the Royal Free Hospital-Nutrition Prioritization Tool were used to evaluate the nutritional status of the patient. RESULTS A total of 370 patients was included in this study, including 177 malnutrition patients, accounting for 45.29%, and the scores and total scores of the patients in the malnutrition group were lower than those in the normal group. The measured values of Na+, Alb, PA, T-Bil, TC, TLC, Hb, and RBC were all lower than those of the normal group, and the difference was statistically significant. The overall complication rate of the patients in the malnourished group was 89.61%, and that of the normal group was 39.78%. Multifactorial logistic regression analysis was performed with nutritional level as the dependent variable (normal = 0, malnutrition = 1), and the above indicators of variability (Na+, Alb, PA, T-Bil, TC, PT, Hb, RBC, HG, and HeLMS scores) as the independent variables. The results showed that Na+, Hb were the influencing factors of nutritional level (P< 0.05). CONCLUSION The incidence of malnutrition in cirrhotic patients included in this study was at a moderate level, and the nutritional literacy of these patients was low. In addition, the level of serum sodium, Hemoglobin can affect the nutritional level of patients with cirrhosis.

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评估与肝硬化患者营养状况相关的风险因素：病例对照研究

背景肝硬化是世界上最常见的临床疾病之一。肝硬化患者有许多并发症，如自发性腹膜炎、肝性脑病等。营养不良是肝硬化患者最常见的并发症之一，也是影响患者预后的关键因素。本研究旨在探讨肝硬化营养状况的新因素。方法选取2019年1月至2023年1月哈尔滨医科大学附属第四医院收治的肝硬化患者共370例。将患者分为营养不良组和正常组。测量两组患者的体重、身高、中臂围（MAC）和肱三头肌皮褶厚度（TSF）。计算体重指数（BMI）和中臂肌围（MAMC）。结果本研究共纳入 370 例患者，其中营养不良患者 177 例，占 45.29%，营养不良组患者的评分和总分均低于正常组。Na+、Alb、PA、T-Bil、TC、TLC、Hb、RBC 的测量值均低于正常组，差异有统计学意义。营养不良组患者的总并发症发生率为 89.61%，正常组为 39.78%。以营养水平为因变量（正常=0，营养不良=1），上述变异指标（Na+、Alb、PA、T-Bil、TC、PT、Hb、RBC、HG 和 HeLMS 评分）为自变量，进行多因素逻辑回归分析。结果显示，Na+、Hb 是营养水平的影响因素（P< 0.05）。结论本研究纳入的肝硬化患者营养不良发生率处于中等水平，这些患者的营养知识水平较低。此外，血清钠、血红蛋白水平也会影响肝硬化患者的营养水平。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.