Comparison of the effect of combination therapies in the treatment of large varicose ulcers: A real-world cohort study

IF 2.6 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Science Progress Pub Date : 2024-09-18 DOI:10.1177/00368504241283352

Fangfang Wen, Hailiang Xie, Minggui Lai, Guofu Zheng, Yuancai Xie, Xiaochun Liu

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Abstract

Objectives:The primary treatment for varicose ulcers is to address the underlying cause of venous hypertension, additionally, split-thickness skin transplantation (ST) is an effective option for large ulcers. The aim of this study was to compare the efficacy of venous surgery with or without split-thickness ST in the management of varicose ulcers (diameter ≥6 cm).Methods:Patients with varicose ulcers between 2013 and 2023 were included in the real-world retrospective cohort study. The endovenous microwave ablation/endovenous laser ablation-high ligation-foam sclerotherapy-compression therapy + ST group (EMA/EVLA-CT-HL-FS + ST) consisted of 32 patients, while the EMA/EVLA-CT-HL-FS group consisted of 48 patients.Results:A difference in ulcer healing time was found between the two groups (the hazard ratio [HR] was 4.4, 95% CI [2.3–8.2], P < 0.0001). However, the healing rate did not differ between the two groups at 6 and 12 months postoperatively.Conclusion:ST has been shown to expedite ulcer healing and ameliorate the symptoms of VVs in the early stages of treatment, while its intermediate to long-term efficacy for ulcer healing and overall patient quality of life may be limited.

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比较联合疗法治疗大面积静脉曲张溃疡的效果：真实世界队列研究

目的：静脉曲张溃疡的主要治疗方法是解决静脉高压的根本原因，此外，分层厚皮移植术（ST）也是治疗大面积溃疡的有效方法。本研究旨在比较静脉手术联合或不联合分层厚皮移植治疗静脉曲张溃疡（直径≥6厘米）的疗效。结果：两组患者的溃疡愈合时间存在差异（危险比 [HR] 为 4.4，95% CI [2.3-8.2]，P <0.0001）。结论：ST 在治疗早期可加快溃疡愈合并改善 VVs 症状，但其对溃疡愈合和患者整体生活质量的中长期疗效可能有限。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Progress Multidisciplinary-Multidisciplinary

CiteScore

3.80

自引率

0.00%

发文量

119

期刊介绍： Science Progress has for over 100 years been a highly regarded review publication in science, technology and medicine. Its objective is to excite the readers'' interest in areas with which they may not be fully familiar but which could facilitate their interest, or even activity, in a cognate field.