Gentiopicroside Ameliorates Sepsis-Induced Acute Lung Injury via Inhibiting Inflammatory Response.

IF 2.1 4区医学 Q3 RESPIRATORY SYSTEM

Canadian respiratory journal Pub Date : 2024-09-05 DOI:10.1155/2024/1068326

Mu Hu,Hangxiang Du,Yang Xu,Yan Wang

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引用次数: 0

Abstract

Sepsis is a systemic inflammatory reaction syndrome caused by infections. Acute lung injury (ALI) occurs first and most frequently in patients with sepsis. Gentiopicroside (GPS), which originates mostly from Gentiana, is classified as a secoiridoid glycosides. Terpenoid glycosides have various biological effects, including liver protection, blood glucose and cholesterol level management, and anti-inflammatory and antitumor effects. However, presently, the biochemical foundation and mechanism of the anti-inflammatory effects of GPS in sepsis-induced ALI have not been explained. In the present study, we established a rat model of sepsis ALI induced by cecal ligation and puncture. This enables us to observe the effects of GPS therapy, which significantly reduced the inflammatory response (TNF-α, IL-1β, and IL-6), nitrogen stress, oxidative stress, and severity of ALI at both the whole animal and molecular levels. In addition, GPS ameliorates LPS-induced ALI via regulation of inflammatory response and cell proptosis in BEAS-2B. This study provides a theoretical basis for treating sepsis-induced ALI with GPS.

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龙胆草甙通过抑制炎症反应改善败血症诱发的急性肺损伤

败血症是一种由感染引起的全身炎症反应综合征。急性肺损伤（ALI）在败血症患者中最先发生，也最常见。龙胆草甙（Gentiopicroside，GPS）主要来源于龙胆草，属于仲萜类甙。萜类苷具有多种生物效应，包括保护肝脏、控制血糖和胆固醇水平、抗炎和抗肿瘤作用。然而，目前 GPS 在败血症引起的 ALI 中抗炎作用的生化基础和机制尚未得到解释。在本研究中，我们建立了一个由盲肠结扎和穿刺诱导的大鼠败血症 ALI 模型。GPS能在动物整体和分子水平上显著降低炎症反应（TNF-α、IL-1β和IL-6）、氮应激、氧化应激和ALI的严重程度。此外，GPS 还能通过调节 BEAS-2B 的炎症反应和细胞突眼来改善 LPS 诱导的 ALI。这项研究为利用 GPS 治疗败血症诱发的 ALI 提供了理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Canadian respiratory journal 医学-呼吸系统

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Canadian Respiratory Journal is a peer-reviewed, Open Access journal that aims to provide a multidisciplinary forum for research in all areas of respiratory medicine. The journal publishes original research articles, review articles, and clinical studies related to asthma, allergy, COPD, non-invasive ventilation, therapeutic intervention, lung cancer, airway and lung infections, as well as any other respiratory diseases.