The i-TED Compton Camera Array for real-time boron imaging and determination during treatments in Boron Neutron Capture Therapy

arXiv - PHYS - Medical Physics Pub Date : 2024-09-16 DOI:arxiv-2409.10107

Pablo Torres-Sánchez, Jorge Lerendegui-Marco, Javier Balibrea-Correa, Victor Babiano-Suárez, Bernardo Gameiro, Ion Ladarescu, Patricia Álvarez-Rodríguez, Jean-Michel Daugas, Ulli Koester, Caterina Michelagnoli, Maria Pedrosa-Rivera, Ignacio Porras, Maria José Ruiz-Magaña, Carmen Ruiz-Ruiz, César Domingo-Pardo

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Abstract

This paper explores the adaptation and application of i-TED Compton imagers for real-time dosimetry in Boron Neutron Capture Therapy (BNCT). The i-TED array, previously utilized in nuclear astrophysics experiments at CERN, is being optimized for detecting and imaging 478 keV gamma-rays, critical for accurate BNCT dosimetry. Detailed Monte Carlo simulations were used to optimize the i-TED detector configuration and enhance its performance in the challenging radiation environment typical of BNCT. Additionally, advanced 3D image reconstruction algorithms, including a combination of back-projection and List-Mode Maximum Likelihood Expectation Maximization (LM-MLEM), are implemented and validated through simulations. Preliminary experimental tests at the Institut Laue-Langevin (ILL) demonstrate the potential of i-TED in a clinical setting, with ongoing experiments focusing on improving imaging capabilities in realistic BNCT conditions.

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用于硼中子俘获疗法治疗过程中实时硼成像和测定的 i-TED 康普顿相机阵列

本文探讨了 i-TED 康普顿成像仪在硼中子俘获疗法（BNCT）中用于实时剂量测定的调整和应用。i-TED 阵列以前曾用于欧洲核子研究中心（CERN）的核天体物理学实验，目前正在针对 478 keV 伽马射线的探测和成像进行优化，这对精确的 BNCT 剂量测定至关重要。详细的蒙特卡洛模拟用于优化 i-TED 探测器配置，并提高其在 BNCT 典型的挑战性辐射环境中的性能。此外，还采用了先进的三维图像重建算法，包括背投影和列表模式最大似然期望最大化（LM-MLEM）的组合，并通过模拟进行了验证。Laue-Langevin 研究所（ILL）的初步实验测试证明了 i-TED 在临床环境中的潜力，目前正在进行的实验重点是提高在真实 BNCT 条件下的成像能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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arXiv - PHYS - Medical Physics

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