Delay discounting and nucleus accumbens functional connectivity are related to weight status in adolescents from the ABCD study

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2024-09-18 DOI:10.1111/ijpo.13173

L. Nate Overholtzer, Hedyeh Ahmadi, Katherine Bottenhorn, Eustace Hsu, Megan M. Herting

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引用次数: 0

Abstract

SummaryBackgroundDespite the growing epidemic of paediatric obesity, questions remain regarding potential neural mechanisms for individual risk. Delay discounting is a cognitive process of comparison of valuation between immediate and delayed reward, which has been inconsistently linked to weight status. Moreover, central to the brain's reward system is the nucleus accumbens, a region structurally and functionally altered in obesity.Objectives/MethodsThis study aimed to examine the relationships between two continuous metrics of weight status, performance on a monetary delay‐discounting task and nucleus accumbens functional connectivity in 10–12‐year‐olds from the Adolescent Brain and Cognitive Development (ABCD) Study.ResultsUsing multilevel longitudinal linear modelling, we found greater discounting was associated with higher BMI Z‐scores (BMIz) and waist‐to‐height ratio Z‐scores (WHtRz) (N = 3819). Moreover, we observed functional connectivity of the nucleus accumbens to the cingulo‐opercular, dorsal attention, fronto‐parietal, salience and ventral attention networks were predictive of BMIz (N = 1817). Nucleus accumbens functional connectivity was not found to mediate the association between delay‐discounting behaviour and BMIz.ConclusionsDelay discounting and nucleus accumbens functional connectivity are independently related to weight status in a large sample of early adolescents. A better understanding of the relationship between reward and overeating behaviours may better inform obesity interventions.

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ABCD研究中青少年的延迟折现和伏隔核功能连接与体重状况有关

摘要背景尽管儿科肥胖症日益流行，但有关个人风险的潜在神经机制问题依然存在。延迟折现是一种比较即时奖励和延迟奖励之间价值的认知过程，它与体重状况的关系并不一致。此外，大脑奖赏系统的核心是伏隔核，肥胖症患者的伏隔核在结构和功能上都会发生改变。目标/方法本研究旨在探讨青少年大脑和认知发展（ABCD）研究中 10-12 岁青少年体重状况的两个连续指标、货币延迟贴现任务的表现和伏隔核功能连接之间的关系。结果通过多层次纵向线性建模，我们发现更高的折现率与更高的体重指数 Z 值（BMIz）和腰围身高比 Z 值（WHtRz）相关（N = 3819）。此外，我们还观察到伏隔核与蝶鞍、背侧注意、前顶叶、显著性和腹侧注意网络的功能连接可预测 BMIz（N = 1817）。结论在大量青少年样本中，延迟贴现和伏隔核功能连通性与体重状况有独立的关系。更好地了解奖赏与暴饮暴食行为之间的关系可以更好地为肥胖干预提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.