Evaluation of malignancy in gallbladder tumors using the apparent diffusion coefficient obtained by diffusion‑weighted MRI.

IF 2.5 4区医学 Q3 ONCOLOGY

Oncology Letters Pub Date : 2024-09-04 DOI:10.3892/ol.2024.14666

Shinichiro Yamada,Yuji Morine,Tetsuya Ikemoto,Yu Saito,Hiroki Teraoku,Yuhei Waki,Chiharu Nakasu,Takayuki Noma,Mitsuo Shimada

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Abstract

The utility of the apparent diffusion coefficient (ADC) of diffusion-weighted image (DWI) magnetic resonance imaging was examined for evaluating malignancy and prognosis in gallbladder tumors. A total of 63 patients (benign tumors, n=33; cancer, n=30) were included after surgical resection for gallbladder tumors, and their mean ADC values by DWI were obtained. Cases of advanced gallbladder cancer (n=25) were divided into ADCHigh and ADCLow groups, and clinicopathological factors were compared. In 63 cases, ADC values in advanced gallbladder cancer were significantly lower compared with benign tumors and non-advanced gallbladder cancer (P<0.05), and ADC values in early gallbladder cancer were also significantly lower compared with benign tumors (P<0.05). In 25 advanced gallbladder cancer cases, the ADCLow group tended to have a higher rate of advanced stage disease (P=0.09). Disease-free survival and overall survival (OS) of the ADCLow group were worse compared with the ADCHigh group (P<0.01). In the multivariate analysis of OS, poor differentiation and low ADC value were independent prognostic factors. ADC values may be useful for evaluating tumor malignancies in gallbladder tumors.

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利用弥散加权磁共振成像获得的表观弥散系数评估胆囊肿瘤的恶性程度。

研究了弥散加权成像（DWI）磁共振成像的表观弥散系数（ADC）在评估胆囊肿瘤的恶性程度和预后方面的实用性。共纳入 63 例胆囊肿瘤手术切除患者（良性肿瘤，33 例；癌症，30 例），并获得其 DWI 平均 ADC 值。将晚期胆囊癌病例（25 例）分为 ADCH 高组和 ADCL 低组，并比较临床病理因素。63例晚期胆囊癌的ADC值明显低于良性肿瘤和非晚期胆囊癌（P<0.05），早期胆囊癌的ADC值也明显低于良性肿瘤（P<0.05）。在25例晚期胆囊癌病例中，ADCLow组的晚期率较高（P=0.09）。与 ADCHigh 组相比，ADCLow 组的无病生存期和总生存期（OS）更差（P<0.01）。在 OS 的多变量分析中，分化差和 ADC 值低是独立的预后因素。ADC值可能有助于评估胆囊肿瘤的恶性程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncology Letters ONCOLOGY-

CiteScore

5.70

自引率

0.00%

发文量

412

审稿时长

2.0 months

期刊介绍： Oncology Letters is a monthly, peer-reviewed journal, available in print and online, that focuses on all aspects of clinical oncology, as well as in vitro and in vivo experimental model systems relevant to the mechanisms of disease. The principal aim of Oncology Letters is to provide the prompt publication of original studies of high quality that pertain to clinical oncology, chemotherapy, oncogenes, carcinogenesis, metastasis, epidemiology and viral oncology in the form of original research, reviews and case reports.