New Insights into Contradictory Changes in Brain-Derived Neurotrophic Factor (BDNF) in Rodent Models of Posttraumatic Stress Disorder (PTSD)

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemical Research Pub Date : 2024-09-16 DOI:10.1007/s11064-024-04242-5

Reza Ghaffarzadegan, Shahin Akhondzadeh, Zahra Nikasa, Shadi Hajizamani, Saba Mehrabanifar, Iman Cheraghi, Salar Vaseghi

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Abstract

Post-traumatic stress disorder (PTSD) is a neuropsychiatric disorder that may develop after experiencing traumatic events. Preclinical studies use various methods to induce PTSD-like models such as fear-conditioning, single-prolonged stress (SPS), restraint stress, and social defeat. Brain-derived neurotrophic factor (BDNF) is a crucial neurotrophin in mood regulation. Evidence shows BDNF changes in different neuropsychiatric disorders particularly PTSD. This review examined BDNF alterations in preclinical rodent models of PTSD where we demonstrated a wide range of paradoxical changes in BDNF. We found that the fear-conditioning model produced the most inconsistent alterations in BDNF, and suggest that conclusions drawn from these changes be approached with caution. We suggest that BDNF maladaptive changes in social defeat and restraint stress models may be related to the duration of stress, while the SPS model appears to have more consistent results. Ultimately, we propose that evaluating BDNF alterations in the process of treating PTSD symptoms may not be a reliable factor.

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创伤后应激障碍（PTSD）啮齿动物模型中脑源性神经营养因子（BDNF）矛盾变化的新发现

创伤后应激障碍（PTSD）是一种在经历创伤事件后可能出现的神经精神障碍。临床前研究使用各种方法诱导类似创伤后应激障碍的模型，如恐惧条件反射、单次持续应激（SPS）、束缚应激和社会挫败。脑源性神经营养因子（BDNF）是调节情绪的重要神经营养素。有证据表明，BDNF 在不同的神经精神疾病，尤其是创伤后应激障碍中会发生变化。本综述研究了创伤后应激障碍临床前啮齿动物模型中 BDNF 的变化，我们在这些模型中发现了 BDNF 的多种矛盾变化。我们发现，恐惧条件反射模型产生的 BDNF 变化最不一致，并建议谨慎对待从这些变化中得出的结论。我们认为，社会挫败和束缚应激模型中的 BDNF 适应不良变化可能与应激持续时间有关，而 SPS 模型的结果似乎更为一致。最后，我们建议在治疗创伤后应激障碍症状的过程中评估 BDNF 的变化可能不是一个可靠的因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurochemical Research 医学-神经科学

CiteScore

7.70

自引率

2.30%

发文量

320

审稿时长

6 months

期刊介绍： Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.