Cardiometabolic index is associated with increased bone mineral density: a population-based cross-sectional study

IF 3 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Frontiers in Public Health Pub Date : 2024-09-18 DOI:10.3389/fpubh.2024.1403450

Xujin Wu, Xixin Jin, Wei Xu, Chang She, Liubing Li, Yongtao Mao

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引用次数: 0

Abstract

BackgroundOsteoporosis is a multifactorial bone disease in which lipid metabolism plays an important role. Bone Mineral Density (BMD) measured by Dual-energy X-ray Absorptiometry (DXA) is a critical indicator for diagnosing osteoporosis. The cardiometabolic index (CMI) is a novel metric that combines two quantitative indicators of blood lipids—triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C). This study explores the association between CMI and BMD and seeks to elucidate the role of lipid metabolism in the context of bone health.MethodsBased on the data of the National Health and Nutrition Examination Survey (NHANES) 2017–March 2020-pre-pandemic, weighted multiple linear regression and smooth curve fitting were used to study the relationship between CMI and femoral BMD. Stratified analyses were also conducted for age, gender, BMI, ethnicity, diabetes and hypertension status. And, the saturation threshold effect of CMI was further analyzed using a two-stage linear regression model.ResultThis study enrolled a total of 1,650 participants (48.7% males), with an average age of 63.0 ± 8.6 years. After adjusting for multiple confounding factors, CMI was positively correlated with total femur BMD, trochanter BMD, and intertrochanter BMD, while the correlation with femur neck BMD was not statistically significant. In the fully adjusted model, each unit increase in CMI was associated with a 0.026 (g/cm2) increase in total femur BMD, a 0.022 (g/cm2) increase in trochanter BMD, and a 0.034 (g/cm2) increase in intertrochanter BMD. Subjects in the highest quartile of CMI had a 0.034 (g/cm2) increase in total femur BMD, a 0.035 (g/cm2) increase in trochanter BMD, and a 0.039 (g/cm2) increase in intertrochanter BMD in the fully-adjusted model compared to those in the lowest quartile. In addition, saturation was observed between CMI and total femur BMD, trochanter BMD and intertrochanter BMD, with saturation thresholds of 1.073, 1.431 and 1.073, respectively.ConclusionCMI is strongly associated with BMD, indicating its potential relevance in bone metabolism. However, the role of CMI in the context of bone health, especially regarding osteoporosis risk, requires further investigation in large-scale prospective studies.

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心血管代谢指数与骨矿物质密度增加有关：一项基于人群的横断面研究

背景骨质疏松症是一种多因素骨病，其中脂质代谢起着重要作用。通过双能 X 射线吸收测定法（DXA）测量的骨密度（BMD）是诊断骨质疏松症的关键指标。心脏代谢指数（CMI）是一种新型指标，它结合了血脂的两个定量指标--甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）。本研究探讨了 CMI 与 BMD 之间的关系，并试图阐明脂质代谢在骨健康中的作用。方法基于美国国家健康与营养调查（NHANES）2017 年至 2020 年 3 月大流行前的数据，使用加权多元线性回归和平滑曲线拟合来研究 CMI 与股骨 BMD 之间的关系。还对年龄、性别、BMI、种族、糖尿病和高血压状况进行了分层分析。结果这项研究共招募了 1,650 名参与者（48.7% 为男性），平均年龄为 63.0 ± 8.6 岁。在对多种混杂因素进行调整后，CMI 与总股骨 BMD、转子 BMD 和转子间 BMD 呈正相关，而与股骨颈 BMD 的相关性无统计学意义。在完全调整模型中，CMI 每增加一个单位，股骨总 BMD 就增加 0.026（g/cm2），转子间 BMD 增加 0.022（g/cm2），转子间 BMD 增加 0.034（g/cm2）。在完全调整模型中，与最低四分位数的受试者相比，CMI 最高四分位数的受试者的总股骨 BMD 增加了 0.034（g/cm2），转子 BMD 增加了 0.035（g/cm2），转子间 BMD 增加了 0.039（g/cm2）。此外，还观察到 CMI 与股骨总 BMD、转子 BMD 和转子间 BMD 之间存在饱和关系，饱和阈值分别为 1.073、1.431 和 1.073。然而，CMI 在骨健康方面的作用，尤其是在骨质疏松症风险方面的作用，还需要在大规模的前瞻性研究中进行进一步调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Public Health Medicine-Public Health, Environmental and Occupational Health

CiteScore

4.80

自引率

7.70%

发文量

4469

审稿时长

14 weeks

期刊介绍： Frontiers in Public Health is a multidisciplinary open-access journal which publishes rigorously peer-reviewed research and is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians, policy makers and the public worldwide. The journal aims at overcoming current fragmentation in research and publication, promoting consistency in pursuing relevant scientific themes, and supporting finding dissemination and translation into practice. Frontiers in Public Health is organized into Specialty Sections that cover different areas of research in the field. Please refer to the author guidelines for details on article types and the submission process.