Evaluation of cell adhesion and inflammatory response of chitin and chitosan nanofibers patterned by inkjet printing

IF 2.7 3区 化学 Q2 POLYMER SCIENCE
Tetsuya Katuragawa, Yoshikuni Teramoto
{"title":"Evaluation of cell adhesion and inflammatory response of chitin and chitosan nanofibers patterned by inkjet printing","authors":"Tetsuya Katuragawa, Yoshikuni Teramoto","doi":"10.1002/app.56285","DOIUrl":null,"url":null,"abstract":"Chitin and chitosan nanofibers (ChNF and CtsNF) are promising biomaterials due to their biocompatibility, biodegradability, and non-toxicity. This study investigates the cell adhesion properties and inflammatory responses of CtsNF, ChNF, and their mixtures when patterned on cellophane films using inkjet printing technology, keeping in mind their potential applications as cell culture scaffolds. The viscosities of 0.1 wt% aqueous dispersions of CtsNF, ChNF, and their mixtures were confirmed to be suitable for inkjet printing. Microstructures with varying thicknesses were fabricated by adjusting the printing parameters. Mouse fibroblast cells (L929) and mouse macrophages (RAW264.7) were used to evaluate cell adhesion and inflammatory responses. The results demonstrated that CtsNF microstructures exhibited excellent cell adhesion even for those as thin as ~140 nm and low inflammatory potential. This finding provides valuable insights into the development of advanced biomaterials for medical applications and could be instrumental in optimizing dosage settings for wound healing treatments as well.","PeriodicalId":183,"journal":{"name":"Journal of Applied Polymer Science","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Polymer Science","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/app.56285","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0

Abstract

Chitin and chitosan nanofibers (ChNF and CtsNF) are promising biomaterials due to their biocompatibility, biodegradability, and non-toxicity. This study investigates the cell adhesion properties and inflammatory responses of CtsNF, ChNF, and their mixtures when patterned on cellophane films using inkjet printing technology, keeping in mind their potential applications as cell culture scaffolds. The viscosities of 0.1 wt% aqueous dispersions of CtsNF, ChNF, and their mixtures were confirmed to be suitable for inkjet printing. Microstructures with varying thicknesses were fabricated by adjusting the printing parameters. Mouse fibroblast cells (L929) and mouse macrophages (RAW264.7) were used to evaluate cell adhesion and inflammatory responses. The results demonstrated that CtsNF microstructures exhibited excellent cell adhesion even for those as thin as ~140 nm and low inflammatory potential. This finding provides valuable insights into the development of advanced biomaterials for medical applications and could be instrumental in optimizing dosage settings for wound healing treatments as well.

Abstract Image

评估喷墨打印图案化甲壳素和壳聚糖纳米纤维的细胞粘附性和炎症反应
甲壳素和壳聚糖纳米纤维(ChNF 和 CtsNF)具有生物相容性、生物可降解性和无毒性,是很有前途的生物材料。本研究考虑到 CtsNF、ChNF 及其混合物作为细胞培养支架的潜在应用,采用喷墨打印技术在玻璃纸薄膜上图案化后,研究了它们的细胞粘附特性和炎症反应。经证实,0.1 wt% 的 CtsNF、ChNF 及其混合物水分散体的粘度适合喷墨打印。通过调整打印参数,制造出了不同厚度的微结构。小鼠成纤维细胞(L929)和小鼠巨噬细胞(RAW264.7)被用来评估细胞粘附性和炎症反应。结果表明,CtsNF 微结构即使薄至 ~140 nm,也能表现出极佳的细胞粘附性和较低的炎症潜能。这一发现为开发先进的医用生物材料提供了宝贵的见解,同时也有助于优化伤口愈合治疗的剂量设置。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Applied Polymer Science
Journal of Applied Polymer Science 化学-高分子科学
CiteScore
5.70
自引率
10.00%
发文量
1280
审稿时长
2.7 months
期刊介绍: The Journal of Applied Polymer Science is the largest peer-reviewed publication in polymers, #3 by total citations, and features results with real-world impact on membranes, polysaccharides, and much more.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信