Serum tumor markers: potential indicators for occult lymph node metastasis in clinical T1 − 2N0M0 small cell lung cancer patients

IF 4.7 2区医学 Q1 RESPIRATORY SYSTEM

Respiratory Research Pub Date : 2024-09-16 DOI:10.1186/s12931-024-02941-9

Xu Jiang, Meng-Wen Liu, Lei Miao, Jiu-Ming Jiang, Lin Yang, Meng Li, Li Zhang

引用次数: 0

Abstract

In their letter-to-the-editor entitled “Letter to the Editor: Incidence rate of occult lymph node metastasis in clinical T1 − 2N0M0 small cell lung cancer patients and radiomic prediction based on contrast-enhanced CT imaging: a multicenter study”, Prof. Chen et al. provided insightful comments and suggestions on our original study. We appreciate the authors’ feedback and have conducted a preliminary exploration of the predictive value of serum tumor markers (TMs) for occult lymph node metastasis (OLM) in clinical T1 − 2N0M0 (cT1 − 2N0M0) small cell lung cancer (SCLC) patients. The results indicate that neuron-specific enolase (NSE), carbohydrate antigen 125 (CA125), and squamous cell carcinoma antigen (SCC) have potential predictive value for detecting OLM in cT1 − 2N0M0 SCLC patients. Additionally, further exploration and confirmation through prospective, large-scale studies with robust external validation are needed.

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血清肿瘤标志物：临床 T1 - 2N0M0 小细胞肺癌患者隐匿性淋巴结转移的潜在指标

在题为 "致编辑的信：临床T1 - 2N0M0小细胞肺癌患者隐匿性淋巴结转移发生率及基于对比增强CT成像的放射学预测：一项多中心研究 "的编辑信中，陈教授等对我们的原始研究提出了独到的意见和建议。我们非常感谢作者的反馈意见，并初步探讨了血清肿瘤标志物（TMs）对临床T1 - 2N0M0（cT1 - 2N0M0）小细胞肺癌（SCLC）患者隐匿性淋巴结转移（OLM）的预测价值。结果表明，神经元特异性烯醇化酶（NSE）、碳水化合物抗原125（CA125）和鳞状细胞癌抗原（SCC）对检测cT1 - 2N0M0 SCLC患者的淋巴结转移具有潜在的预测价值。此外，还需要通过前瞻性的大规模研究和强有力的外部验证来进一步探索和确认。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Research 医学-呼吸系统

自引率

1.70%

发文量

314

期刊介绍： Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.