Kidney Beam-A Cost-Effective Digital Intervention to Improve Mental Health

IF 5.7 2区医学 Q1 UROLOGY & NEPHROLOGY

Kidney International Reports Pub Date : 2024-09-02 DOI:10.1016/j.ekir.2024.08.030

Sharlene A. Greenwood, Juliet Briggs, Christy Walklin, Emmanuel Mangahis, Hannah M.L. Young, Ellen M. Castle, Roseanne E. Billany, Elham Asgari, Sunil Bhandari, Nicolette Bishop, Kate Bramham, James O. Burton, Jackie Campbell, Joseph Chilcot, Nicola Cooper, Vashist Deelchand, Matthew P.M. Graham-Brown, Lynda Haggis, Alexander Hamilton, Mark Jesky, Philip A. Kalra, Pelagia Koufaki, Kieran McCafferty, Andrew C. Nixon, Helen Noble, Zoe L. Saynor, Maarten W. Taal, James Tollitt, David C. Wheeler, Thomas J. Wilkinson, Hannah Worboys, Jamie Macdonald

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Abstract

There is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention (DHI) in CKD. In a single-blind, 11 center, randomized controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity DHI or a waitlist control. This study assessed the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6-months, and cost-effectiveness of the intervention. At 6-months, there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 [95% confidence interval, CI: 4.4–7.5] arbitrary units [AU], < 0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness-to-pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. The Kidney BEAM physical activity DHI is a clinically valuable and cost-effective means to improve mental health-related quality of life (HRQoL) in people with CKD (trial registration no. NCT04872933).

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肾束--改善心理健康的经济高效的数字干预措施

在为慢性肾病（CKD）患者提供身体康复服务方面存在不公平现象。肾脏 BEAM 试验评估了体力活动数字健康干预（DHI）在 CKD 中的临床价值和成本效益。在一项单盲、11 个中心的随机对照试验中，340 名患有慢性肾脏病的成年参与者被随机分配到肾脏 BEAM 体力活动数字健康干预或等待名单对照组。这项研究评估了干预组和对照组在 6 个月时肾脏病生活质量简表 1.3 心理成分总结（KDQoL-SF1.3 MCS）的差异以及干预的成本效益。在6个月时，肾脏BEAM与候补对照组的KDQoL MCS得分调整后平均值有显著差异（意向治疗调整后平均值为5.9 [95%置信区间]）：按照每质量调整生命年收益 2 万英镑和 3 万英镑的支付意愿临界值计算，干预具有成本效益的几率分别为 93% 和 98%。肾脏 BEAM 体力活动 DHI 是改善慢性肾脏病患者心理健康相关生活质量（HRQoL）的一种具有临床价值和成本效益的方法（试验登记号：NCT04872933）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Kidney International Reports Medicine-Nephrology

CiteScore

7.70

自引率

3.30%

发文量

1578

审稿时长

8 weeks

期刊介绍： Kidney International Reports, an official journal of the International Society of Nephrology, is a peer-reviewed, open access journal devoted to the publication of leading research and developments related to kidney disease. With the primary aim of contributing to improved care of patients with kidney disease, the journal will publish original clinical and select translational articles and educational content related to the pathogenesis, evaluation and management of acute and chronic kidney disease, end stage renal disease (including transplantation), acid-base, fluid and electrolyte disturbances and hypertension. Of particular interest are submissions related to clinical trials, epidemiology, systematic reviews (including meta-analyses) and outcomes research. The journal will also provide a platform for wider dissemination of national and regional guidelines as well as consensus meeting reports.