Can ultrasound elastography be useful in the diagnosis of poor ovarian response?

IF 1.2 4区医学 Q3 ACOUSTICS

Journal of Clinical Ultrasound Pub Date : 2024-09-18 DOI:10.1002/jcu.23827

Ebru Sahin Gulec, Esra Bahar Gur, Secil Karaca Kurtulmus, Bilgesu Cetinel Kaygun, Esin Kasap, Ahmet Demir

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引用次数: 0

Abstract

ObjectivesThis study aims to compare the elastographic properties of the ovaries of patients with poor ovarian response (POR) with healthy controls by using real‐time ultrasound tissue elastography and to investigate the predictive value of ovarian strain ratio (OSR) in the diagnosis of POR.Materials and MethodsA cross‐sectional study was conducted among infertility patients. OSR measurements of 46 women diagnosed with POR and 41 healthy controls with male infertility were performed by real‐time ultrasound tissue elastography. Ovarian volume, OSR, antral follicle count (AFC), age, body mass index (BMI), anti‐mullerian hormone (AMH), follicle stimulating hormone (FSH), and estradiol (E2) values, were compared between the groups. A receiver operating characteristic curve was used to compare the sensitivity and specificity of OSR, AFC, AMH, FSH, and E2 for POR diagnosis.ResultsPatients with POR were significantly older, had a lower duration of infertility, lower AMH, higher FSH, higher E2, lower AFC and ovarian volume (p < 0.01, p = 0.02, p < 0.01, p < 0.01, p < 0.01, p < 0.01, p < 0.01, respectively). The mean OSR of both ovaries was similar between the groups. For the diagnosis of POR, the sensitivity and specificity for AMH were 97.5% and 100%, for AFC were 86.7% and 97.6%; for FSH were 66.7% and 80.5%, for E2 were 53.3% and 90.2%, respectively.ConclusionsThe significant independent predictors of the POR were AMH, AFC, and FSH, with no additional significant contribution from OSR. However, considering the relationship between POR and ovarian fibrosis, it is recommended to investigate this issue in more comprehensive studies.

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超声弹性成像能否用于诊断卵巢反应不良？

本研究旨在利用实时超声组织弹性成像技术比较卵巢反应不良（POR）患者与健康对照组卵巢的弹性特性，并探讨卵巢应变比（OSR）在诊断 POR 中的预测价值。通过实时超声组织弹性成像技术对 46 名确诊为 POR 的女性和 41 名男性不育症健康对照者进行了卵巢应变比测量。比较了各组之间的卵巢体积、OSR、前卵泡计数（AFC）、年龄、体重指数（BMI）、抗苗勒氏激素（AMH）、促卵泡激素（FSH）和雌二醇（E2）值。用接收器操作特征曲线比较了 OSR、AFC、AMH、FSH 和 E2 对 POR 诊断的敏感性和特异性。结果POR患者的年龄明显偏大，不孕时间较短，AMH较低，FSH较高，E2较高，AFC和卵巢体积较小（分别为p < 0.01, p = 0.02, p < 0.01, p < 0.01, p < 0.01, p < 0.01, p < 0.01）。两组患者卵巢的平均OSR相似。对于 POR 的诊断，AMH 的敏感性和特异性分别为 97.5%和 100%，AFC 的敏感性和特异性分别为 86.7%和 97.6%，FSH 的敏感性和特异性分别为 66.7%和 80.5%，E2 的敏感性和特异性分别为 53.3%和 90.2%。然而，考虑到 POR 与卵巢纤维化之间的关系，建议对这一问题进行更全面的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Ultrasound 医学-核医学

CiteScore

1.90

自引率

0.00%

发文量

248

审稿时长

6 months

期刊介绍： The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography. The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents. JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.