Christensenella minuta protects and restores intestinal barrier in a colitis mouse model by regulating inflammation

IF 7.8 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2024-09-19 DOI:10.1038/s41522-024-00540-6

Camille Kropp, Kevin Tambosco, Sead Chadi, Philippe Langella, Sandrine P. Claus, Rebeca Martin

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Abstract

Christensenella minuta DSM 22607 has recently been suggested as a potential microbiome-based therapy for inflammatory bowel disease (IBD) because it displays strong anti-inflammatory effects both in vitro and in vivo. Here, we aimed to decipher the mechanism(s) underlying the DSM 22607-mediated beneficial effects on the host in a mouse model of chemically induced acute colitis. We observed that C. minuta plays a key role in the preservation of the epithelial barrier and the management of DNBS-induced inflammation by inhibiting interleukin (IL)-33 and Tumor necrosis factor receptor superfamily member 8 (Tnfrsf8) gene expression. We also showed that DSM 22607 abundance was positively correlated with Akkermansia sp. and Dubosiella sp. and modulated microbial metabolites in the cecum. These results offer new insights into the biological and molecular mechanisms underlying the beneficial effects of C. minuta DSM 22607 by protecting the intestinal barrier integrity and regulating inflammation.

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小克氏菌通过调节炎症保护和恢复结肠炎小鼠模型的肠道屏障

Christensenella minuta DSM 22607最近被认为是一种潜在的基于微生物的炎症性肠病（IBD）疗法，因为它在体外和体内都显示出很强的抗炎作用。在这里，我们的目的是在化学诱导的急性结肠炎小鼠模型中破译 DSM 22607 介导的对宿主有益作用的机制。我们观察到，C. minuta 通过抑制白细胞介素（IL）-33 和肿瘤坏死因子受体超家族成员 8（Tnfrsf8）基因的表达，在保护上皮屏障和控制 DNBS 诱导的炎症中发挥了关键作用。我们还发现，DSM 22607 的丰度与 Akkermansia sp.和 Dubosiella sp.呈正相关，并能调节盲肠中的微生物代谢物。这些结果为我们提供了保护肠道屏障完整性和调节炎症的生物学和分子机制的新见解。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.